Uspeshnoe lechenie ostrogo toksicheskogo gepatita u patsienta so steatozom pecheni i metabolicheskim sindromom
- 作者: Russkikh A.V.1
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- 期: 编号 11 (2012)
- 页面: 68-73
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279678
- ID: 279678
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详细
The combination of history of alcohol consumption and liver steatosis, according to different authors, may occur in 50 % of cases. Clear differentiation of acute alcoholic hepatitis (AAH) and nonalcoholic steatohepatitis (NASH) is not always possible, because these conditions are often combined in clinical practice. This clinical example illustrates the “crossing" of the two hepatic diseases, which can be mutual confounders for two pathological processes - AAH and NASH. Currently, for a comprehensive treatment of the AAH and NASH, well-studied and safe combination of ornithine, ademetionine, pentoxifylline, metformin, ursodeoxicholic acid and thioctic acid (Thiogamma) should be used. Taking into account the participation of thioctic acid in antioxidant protection, administration of Thiogamma can be considered as reasonable treatment for all patients with metabolic syndrome and toxic liver injury.
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参考
- Яковенко Э.П., Григорьев П.Я., Агафонова Н.А. и др. Метаболические заболевания печени: проблемы терапии// Фарматека 2003. № 10.
- Практическая гепатология / Под ред. Н.А. Мухина. М., 2005.
- Mendez-Sanchez N, Arrese M, Zamora-Valdes D, Uribe M, et al. Current concepts in pathogenesis of nonalcoholic fatty liver disease. Liver Int 2007;27(4):423-33.
- Arivazhagan P, Panneerselvam C. Effect of DL-alpha-lipoic acid on tissue nucleic acid contents in aged rats. Pharmacol Res 2000;42(3):223-6.
- Roberts E. A. Pediatric nonalcoholic fatty liver disease (NAFLD): A "growing" problem? J Hepatol 2007;46(6):1133-42.
- Konrad T, Vicini P, Kusterer K, et al. Alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22(2):280-87.
- Tilg H, Kaser A. Management of acute alcoholic hepatitis. In: Prevention and Intervention in Liver Disease. IASL-EASL Postgraduate Course. Madrid, 2002:28-37.
- Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid mechanisms of action and clinical use in hepatobiliary disorders. J Hepatol 2001;35:134-46.
- Brunt EM. Nonalcoholic steatohepatiatis. Semin Liver Dis 2004;24:3-20.
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