Tsirroz pecheni, kliniko-patogeneticheskie aspekty


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In economically developed countries, liver cirrhosis (LC) is one of the six leading causes of death of patients from 35 to 60 years, accounting for 14-30 per 100,000 population. The main etiological factors of the disease are viral hepatitis B, C, D, alcohol, and drugs. The advantages and disadvantages of the morphological and non-invasive methods of diagnosis of LC are evaluated. The clinical manifestations of the disease and the mechanisms of their development are discussed in detail. Pathogenetic variants of cytolytic syndrome, and the basic mechanisms of the LC progression as the point of application of drug therapy are presented. The frequency of detection, mechanisms of development and clinical significance of intestinal dysbiosis in cirrhotic patients are emphasized.

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