Klinicheskoe znachenie farmakologicheskogo vliyaniya na vospalenie v malykh dykhatel'nykh putyakh pri bronkhial'noy astme


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Small airways are involved in persistent inflammation and functional disorders in bronchial asthma (BA). The influence on distal lung inflammation is possible with the use of extra-fine inhaled glucocorticosteroids (ICS) and their combination with long-acting β-agonists (LABA), the clinical effect is achieved by using lower doses of ICS. Recent research on the efficacy of combined ICS/ LABA for BA patients in real-life clinical practice, and analysis of clinical efficacy of fixed combinations of ICS/LABA compared with ICS and LABA delivered in separate inhalers have demonstrated the benefits of extra-fine beclomethasone/formoterol compared with combinations of non extra-fine combinations of ICS/LABA for achieving BA control and quality of life of patients.

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N. Nenasheva

参考

  1. Balzar S, Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002;20:254-59.
  2. Sorkness RL, Bleecker ER, Busse WW, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008;104:394-403.
  3. Scichilone N, Battaglia S, Olivieri D, Bellia V. The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1? Allergy 2009:64:1563-69.
  4. Contoli М, Bousquet J, Fabbri L, et al. The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 2010;65;141-51.
  5. Ненашева Н.М. Роль мелких дыхательных путей при бронхиальной астме//Атмосфера. Пульмонология и аллергология 2010. № 4. С. 30-35.
  6. Будневский А.В., Бурлачук В.Т., Олышева И.А. Терапевтические подходы к контролю воспаления на уровне мелких бронхов при бронхиальной астме // Российский аллергологический журнал 2010. № 9. С. 85-94.
  7. Huchon G, Magnussen H, Chuchalin A, et al. Lung function and asthma control with beclomethasone and formoterol in single inhaler. Respir Medicine 2009;103:41-9.
  8. Papi A, Paggiaro P, Nicolini G, et al. Beclometasone/formoterol vs fluticasone/salmeterol inhaled combination in moderate to severe asthma. Allergy 2007;62:1182-88.
  9. Papi A, Paggiaro P, Nicolini G, et al. Beclometasone/formoterol vs budesonide/formoterol combination therapy in asthma. Eur Respir J 2007;29:682-89.
  10. Barnes PJ, Nicolini G, Bizzi A, et al. Do inhaled corticosteroid/long-acting beta2-agonist fixed combinations provide superior clinical benefits compared with separate inhalers? A literature reappraisal. Allergy Asthma Proc 2012; 33:140-44.
  11. Global Initiative for Asthma. Available at: http:// www.ginasthma.com
  12. Greening AP, Ind PW, Northfield M, and Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Lancet 1994;344:219-24.
  13. Woolcock A, Lundback B, Ringdal N, Jacques LA. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996,153:1481-88.
  14. Pauwels RA, Lofdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997;337:1405-11.
  15. Matz J, Emmett A, Rickard K, Kalberg C. Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: An analysis of asthma exacerbations. J Allergy Clin Immunol 2001;107:783-91.
  16. Bateman ED, Britton M, Carrillo J, et al. Salmeterol/fluticasone combination inhaler: A new, effective and well tolerated treatment for asthma. Clin Drug Investig 1998;16:193-201.
  17. Chapman KR, Ringdal N, Backer V, et al. Salmeterol and fluticasone propionate (50/250 microg) administered via combination Diskus inhaler: As effective as when given via separate Diskus inhalers. Can. Respir J 1999;6:45-51.
  18. Aubier M, Pieters WR, Schlosser NJ, Steinmetz KO. Salmeterol/fluticasone prorionate (50/500 vicrog) in combination in a Diskus inhaler (Seretide) is effective and safe in the treatment of steroid-dependent asthma. Respire Med 1999;93:876-84.
  19. Zetterstrom O, Buhl R, Mellem H, et al. Improved asthma control with budesonide/formoterol in a single inhaler compared with budesonide alone. Eur Respire J 2001;18:262-68.
  20. Rosenhall L, Heinig JH, Lindqvist A, et al. Budesonide/formoterol (Symbicort) is well tolerated and effective in patients with moderate persistent asthma. Int J Clin Pract 2002;56:427-33.
  21. Rosenhall L, Elvstrand A, Tilling B, et al. One-year safety and efficacy of budesonide/formoterol in a single inhaler (Symbicort Turbuhaler) for the treatment of asthma. Respir Med 2003;97:702-08.
  22. Jenkins C, Kolarikova R, Kuna P, et al. Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma. Respirology 2006;11:276-86.
  23. Chervinsky P, Baker J, Bensch G, et al. Patient-reported outcomes in adults with moderate to severe asthma after use of budesonide and formoterol administered via 1 pressurized metered-dose inhaler. Ann Allergy Asthma Immunol 2008;101:463-73.
  24. Bodzenta-Lukaszyk A, Pulka G, Dymek A, et al. Efficacy and safety of fluticasone and formoterol in a single pressurized metered dose inhaler. Respir Med 2011;105:674-82.
  25. Fabbri LM, Nicolini G, Olivery D, et al. Inhaled beclometasone dipropionate/formoterol extrafine fixed combination in treatment of asthma: evidence and future perspectives. Expert Opinion Pharmacother 2008;9:479-90.
  26. Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? Am J Respir Crit Care Med 2004;170:836-44.
  27. Gibson PG, Powell H, Ducharme FM. Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations. J Allergy Clin Immunol 2007;119:344-50.
  28. Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin 2004;20:1403-18.
  29. Черняк Б.А. Клиническая практика ведения больных бронхиальной астмой в России: результаты мониторинга // Атмосфера. Пульмонология и аллергология 2009. № 3. С. 23-28.
  30. Demoly P, Gueron B, Annunziata K, et al. Update on asthma control in five European countries: results of a 2008 survey Eur Respir Rev 2010;19:150-57.
  31. Haughney J, Price D, Kaplan A, et al. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med 2008 102(12):1681-93.
  32. Muller V, Galffy G, Eszes N, et al. Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation. BMC Pulmonary Medicine 2011 11:40-5.
  33. Allegra L, Cremonesi G, Girbino G, et al. Real-life prospective study on asthma control in Italy: Cross-sectional phase results. Respiratory Medicine (2011), doi: 10.1016/j. rmed.2011.10.001
  34. De Backer W, Devolder A, Poli G, et al. Lung Deposition of BDP/Formoterol HFA pMDI in Healthy Volunteers, Asthmatic, and COPD Patients. J Aerosol Med Pulm Drug Delivery 2010;23:1-12.

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