Sovremennaya kontseptsiya fenotipirovaniya bronkhial'noy astmy - vzglyad klinitsista


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

The problems of the pathophysiological and clinical heterogeneity of various forms of bronchial asthma (BA) are discussed. The current stage of the study of BA is marked by the appearance of a new direction - phenotyping of disease and endotyping associated with phenotyping. This will allow for a differentiated approach to the treatment, the development of individual schemes of treatment of this disease, and effective algorithms for the use of drugs, and thus, will allow to maximize the therapeutic effect and avoid off-label use of drugs.

全文:

受限制的访问

作者简介

D. Fomina

L. Goryachkina

参考

  1. Hashimoto S, Bel EH. Current treatment of severe asthma. Clin Exp Allergy 2012;42(5):693-705.
  2. Chung et al. Difficult-to-treat Severe Asthma.European Respiratory Monograph (51Book) 2011.
  3. Wenzel S. Severeasthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy. 2012;42(5):650-58.
  4. Agache I, Akdis C, et al. Untangling asthmaphenotypes and endotypes. Allergy 2012;67(7):835-46.
  5. Wenzel S. Focus on Asthma. Nature Medicine 2012;18(5).
  6. Wenzel SE. Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both? Am J Respir Crit Care Med 2004; 170(6):579-80.
  7. Wensel SE. Review Asthma:defining of the persistent adult phenotypes. Lancet 2006;368:804-13.
  8. Kharitonov SA, Barnes PJ. Exhaled biomarker. Chest 2006;130(5);1541-46.
  9. Дугарова И.Д., Анаев Э.Х., Чучалин А.Г. О роли цитокинов при бронхиальной астме// Пульмонология. 2009. № 4. С. 96-101.
  10. Vrlik M, Dzurilla M, Bucova M, et al. Asthma bronchiale phenotypes and their treatment - a current view. Acta med mart 2009;9(3).
  11. Fahy JV. Eosinophilic and neutrophilic inflammation in asthma. Insights from clinical studies. Proc Am Thorac Soc 2009;6:256-59.
  12. Tillie-Leblond I, Montani D, Crestani B, et al. Relation between inflammation and symptoms in asthma. Allergy 2009;64(3):354-67.
  13. Cowan DC, Cowan J, Palmay R, et al. The effects of steroid therapy on inflammatory cell subtypes in asthma. 2010. Downloaded from thorax.bmj. com on February 4, 2010. Published by group. bmj.com.
  14. Berry M, Morgana, Shaw D, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007;62(12):1043-49.
  15. Cowan DC, Cowan J, Palmayr, et al. the effects of steroid therapy on inflammatory cell subtypes in asthma. 2010. Downloaded from thorax.bmj. com on February 4, 2010. Published by group. bmj.com.
  16. Telenga E, et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy. 2012;67(8):1060-68.
  17. McGrath KW, et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir 2012;185:612-19.
  18. Macedo P, Hew M, Norrego A, et al. Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma. Clin Exp Allergy 2009; 39: 1668-76.
  19. Hastie AT, Moore WC, Meyers DA, et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy ClinImmunol 2010;1028-36.
  20. Lavinskiene S, et al. Peripheral Blood Neutrophil Activity During Dermatophagoidespteronyssinus-Induced Late-Phase Airway Inflammation in Patients with Allergic Rhinitis and Asthma, Inflammation. 2012;35(4):1600-09.
  21. Szefler SJ, et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol 2005;115:233-42.
  22. Фомина Д.С., Горячкина Л.А., Ненашева Н.М. и др. Активность нейтрофильной эластазы сыворотки крови у больных атопической бронхиальной астмой. Пульмонология. 2010. № 2. С. 82-6.
  23. Cosmi L, Liotta F, Maggi E, et al. and Annunniato. TH17 cells: new players in asthma pathogenesis. Allergy 2011; 989-98.
  24. Innovative Medicines Initiative(MIM). http:// www.imi.europa.eul/
  25. Auffray C, Adcock IM, Chung F, et al. An integrative systems biology approach for understanding of pulmonary disease. Chest 2010;137:1410-16.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2013
##common.cookie##