No 1s (2013)

Due to growing number of unpredictable, life-threatening, fast-developing cases of anaphylaxis in all age groups, doctors of all specialties focus on the key issues of assessment of individual risk factors, recognition of clinical symptoms and the choice of strategies for interventions aimed to improvement of management and prognosis of potentially fatal anaphylactic reactions. The importance of the issues is highlighted in numerous publications on the diagnosis, treatment and prevention of anaphylaxis, including illustrated clinical guidance on anaphylaxis 2011. This document of World Allergy Organization included recommendations of more than 100 leading experts from all over the world and based on the best evidence-based research data, was supplemented with new information in 2012. The article presents the fundamental principles of the guidelines, which doctor of any specialty needs to know. These include clinical criteria for the diagnosis of anaphylaxis, the need for use of epinephrine as a first-line drug in anaphylaxis, advanced laboratory diagnostic methods for asymptomatic sensitization, new strategies of immunomodulation for the prevention of nutritional and insect anaphylaxis, and debating issues of the use of corticosteroids and antihistamines

Today proved the important role of hydration of the skin and applying emollient/moisturizer in the acute and chronic phases of atopic dermatitis (AtD). In particular, the use of anti-inflammatory drugs, which include topical corticosteroids (TGKS) and topical calcineurin inhibitors are recommended only after proper skin care: cleansing and hydration of the skin with moisturizers/emollients. Described in the literature are cases of equivalent effectiveness of moisturizers and TGKS for patients with AtD. In general, skin hydration and moisturizing agents greatly increase the effectiveness of the treatment AtD and quality of life of these patients. In addition, wetting agents have a unique protective effect even before the severe symptoms of acute illness, and dramatically reduce the amount of medication. At the same time supporting basic therapy does not replace drugs with anti-inflammatory action (TGKS, topical calcineurin inhibitors).

The article is dedicated to the problem of atopic dermatitis (AD) in children. Information on the pathogenesis, clinical manifestations of the disease, and the choice of external anti-inflammatory therapy is presented. The article discusses the results of the study involving 22 children with AD, which demonstrated high efficacy and good tolerability of Lokoid lipocrem and Locoid crelo in the treatment of moderate-to-severe AD in infants. These drugs have good cosmetic properties, well sop through the skin, leave no greasy marks, and improve the quality of life for patients.

Article is devoted to the problem of clinical allergy - diagnosis and treatment of pollinosis. The article highlights the prevalence of pollinosis, discusses the etiology, pathogenesis of the disease. Discussed in detail features of the course, the modern methods of diagnosis, prevention and therapy of pollinosis. The features of the drug Prevalin - nasal spray for topical application.

The article discusses the properties of antihistamines in the light of the basic principles of rational pharmacotherapy. Ebastine (Kestine) - high-effective new generation antihistamine that meets all the requirements of the modern antihistamines. The presence of different dosage forms, varying by dosages and the onset of action, allows to consider Kestine as a drug of choice, which affects the quality of life of patients with various manifestations of allergic diseases.

Allergic rhinitis is a serious medical and social problem associated with a high morbidity and high economic expenses for rhinitis management. The conducted studies demonstrated expediency of treatment with intranasal steroids, the most suitable medication for a prevention strategy, because they target the inflammatory cascade at multiple points and yield measurable symptom relief when administered preventively.