OSOBENNOSTI TEChENIYa YaZVENNOGO KOLITA NA FONE TERAPII INFLIKSIMABOM
- 作者: Shapina M.V1, Khalif I.L1, Golovenko A.O1, Kashnikov V.N1
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隶属关系:
- 期: 编号 15 (2015)
- 页面: 40-43
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/288186
- ID: 288186
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This retrospective study was aimed to the assessment of further course of the disease in patients with ulcerative colitis (UC), who initially had response to infliximab induction course and had relapses occurred against the background of maintenance therapy. There were 46 patients treated with infliximab during the year. Therapy was administered in the case of hormone dependence or hormone resistance. In the case of relapse, dose optimization before next administration was recommended. In the case of mild-to-moderate activity of relapse, therapeutic dose of 5-acetylsalicylic acid was prescribed to patients before the next administration. In severe attack and high activity, systemic corticosteroids were administered, and surgical treatment was considered. The study identified four types of course of UC on background of anticytokine therapy, depending on the frequency and timing of relapses. However, further observation of a large number of patients to clarify the frequency of occurrence of these types and their application in clinical practice is required.
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