Активные метаболиты витамина D в лечении остеопороза и профилактике переломов


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Аннотация

Обзор посвящен клиническим эффектам активных метаболитов витамина D, которые обладают многоплановым действием на разные органы и ткани, имея оптимальный профиль безопасности, в связи с чем области применения и возрастной диапазон пациентов, которым можно назначать эти препараты, достаточно широки. Поскольку наиболее убедительные результаты были показаны в отношении увеличения минеральной плотности кости в 2-5 раз, снижения риска переломов в 2 раза и уменьшения риска падений в 3,5 раза, аналоги D-гормона могут активно использоваться в управлении риском переломов, связанных с первичным и вторичным остеопорозом.

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И. А Скрипникова

ФГБУ ГНИЦПМ Минздрава России

Email: ISkripnikova@gnicpm.ru
д.м.н., рук. отдела профилактики остеопороза Москва

Список литературы

  1. Kanis J.A., McCloskey E.V., Johansson H., Cooper C., Rissoli R., Reginster J.-Y. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int.2013;24:23-57.
  2. Kanis J.A, Johnell O., Oden A., Sembo I., Redlund-Johnell I., Dawson A., De Laet C., Jonsson B. Long term risk of osteoporotic fracture in Malmo. Osteoporos Int.2000; 11:669-74.
  3. Elliot-Gibson V., Bogoch E.R., Jamal S.A., Beaton D.E. Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic review. Osteoporosis Int. 2004;15:767-78.
  4. Haaland D.A., Cohen D.R., Kennedy C.C., Khalidi N.A., Adachi J.D., Papaioannou A. Closing the osteoporosis care gap: increased osteoporosis awareness among geriatrics and rehabilitation teams. BMC Geriatr. 2009;9:28.
  5. Sambrook P., Cooper C. Osteoporos. Lancet. 2006;367:2010-18.
  6. Boonen S., Vanderschueren D., Haentjens P., Lips P. Calcium and vitamin D in the prevention and treatment of osteoporosis - a clinical update. J Intern Med 2006;258:539-552.
  7. Group D. Patient level pooled analysis of 68500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010;340:b5463.
  8. Tang B.M., Eslick G.D., Nowson C., Smith C., Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370:657-66.
  9. Avenel A, Gillespie W.J., Gillespie J.D., O'Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Library. 2009;Issue 2. http/www.the-cochranelibrary.com
  10. Boonen S., Lips P., Bouillon R., Bischoff-Ferrari H.A., Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative meta-analysis of randomized controlled trials. Clin. Endocrinol.Metab. 2007;92:1415-23.
  11. Boonen S., Bischoff-Ferrari H.A., Cooper C., Lips, P., Ljunggren O., Meunier P.J., Reginster J.Y. Adressing the musculoskeletal components of fracture risk with calcium and vitamin D; a review of the evidence. Calcif. Tissue Int. 2006;78:257-70.
  12. Gallagher J.C., Fowler S.E., Detter J.R. Combination treatment with estrogen and calcitriol in the prevention of age-relation bone loss. J. Clin. Endocrinol. Metab. 2001; 86:3618-28.
  13. Gallagher J.C. The effects of calcitriol on falls and fractures and physical performance tests. J. Steroid. Biochem. Mol. Biol. 2004; 89-90:497-501.
  14. Ones K., Schacht E., Dukas L. Effects of combined treatment with alendronate and alfacal-cidol on bone mineral density and bone turnover in poatmenopausal osteoporosis: a two-years randomized multiarm controlled trial. Inrernet J. Endocrinol. 2007;4:published online.
  15. Richy F., Schacht E., Bruyere O., Ethgen O., Gourlay M., Reginster J.Y. Vitamin D Analogues Versus Native Vitamin D in Preventing Bone Loss and Osteoporosis-Related Fractures: A Comparative Meta-analysis. Calcif Tissue Int. 2005;76:176-86
  16. Richy F., Dukas L., Schacht E. Differential effects of D-Hormone analogs and native vitamin D on the risk of falls: a comparative meta-analysis. Calcific Tissue Int. 2008. Epub ahead of print.
  17. de Nijs R. N., Jacobs J. W., Algra A., Lems W. F., Bijlsma J.W. Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with meta-analysis of randomized controlled trials including organ transplantation studies. Osteoporos. Int. 2004;15(8):589-602.
  18. Lekamwasam S., Adachi J. D., Agnusdei J. Bilezikian J., Boonen S., Borgstrom F., Cooper C. A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis Osteoporos Int 2012; 23(9): 2257-76.
  19. Jarvinen T.L.N., Sievanen H., Khan K.M., Heinonen A., Kannus P. Shifting the focus in fracture prevention from osteoporosis to falls. Br. Med. J. 2008;336;124-26.
  20. Kannus P., Sievanen H., Palvanen M., Jarvinen T., Parkkari J. Prevention of falls and consequent injuries in elderly people. Lancet. 2005;366:1885-93.
  21. Barret-Connor E., Weiss T.W., McHorney C.A., Miller P.D., Siris E.S. Predictors of falls among postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos. Int. 2009;20:715-22.
  22. Group D. Patient level pooled analysis of 68500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010; 340:b5463.
  23. Ducas L., Bischoff H.A,, Lindpaintner L.S., Schacht E., Birkner-Binder D., Damm T.N., Thalmann B., Stahelin H.B. Alfacalcidol Reduces the Number of Fallers in a Community-Dwelling Elderly Population with a Minimum Calcium Intake of More Than 500 mg Daily. J. Am. Geriatr. Soc. 2004;52(2):230-36.
  24. Schacht E., Richy F., Reginster J.-Y. The therapeutic effects of alfacalcidol on bone strength muscle metabolism and prevention of falls and fractures. J. Musculoscelet. Neuronal. Interact. 2005;5(3):273-384.
  25. Ducas L., Schacht E., Mazor Z. Treatment with alfacalcidol in elderly people significantly decreases the high risk of falls associated with a low creatinine clearance of №65 ml/min. Osteoporos. Int. 2005;16(2):198-203.
  26. Sorensen O.H., Lund B.I., Saltin B., Lund B.J., Andersen R.B., Hjorth L., Melson F., Mosekilde F. Myopathy in bone loss of ageing: improvement by treatment with 1-alphahydroxycholecalcif-erol and calcium. Clin. Sci. 1979;56:157-61.
  27. Verhaar H.J.J., Samson M.M., Jansen P.AF., de Vreede P.L., Manten J.W., Duursma S.A. Muscle strength, functional mobility and vitamin D in older women. Aging Clin. Exp. Res. 2000;12:455-60.
  28. Orimo H. Clinical application of 1a(OH)D3 in Japan. Act. Rheumatol.1994;89:27.

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