HCV-ASSOCIATED LIVER CIRRHOSIS: MODERN POSSIBILITIES OF INTERFERON-FREE THERAPY


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详细

The article presents the results of combination therapy using antiviral drugs with direct action as follows: daclatasvir 60 mg 1 time a day plus asunaprevir 100 mg twice a day for 24 weeks with the participation of 29 cirrhotic patients in the outcome of chronic hepatitis C with 1b-genotype. Results of use of interferon-free combination asunaprevir+daclatasvir allows to consider it as a safe and effective scheme of choice in patients with HCV-associated liver cirrhosis.

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作者简介

I. Bakulin

SBHCI “Moscow Clinical Research Center" of Moscow Healthcare Department

Email: igbakulin@yandex.ru
MD, Prof., Head of the Department of Hepatology Moscow

D. Abdurakhmanov

SBEI HPE “First MSMU n.a.I.M.Sechenov" of RMPH; MSU n.a. M.I. Lomonosov

Moscow

N. Shalikiani

SBHCI “Moscow Clinical Research Center" of Moscow Healthcare Department

Moscow

A. Polukhina

SBHCI “Moscow Clinical Research Center" of Moscow Healthcare Department

Moscow

Yu. Matveeva

SBHCI “Moscow Clinical Research Center" of Moscow Healthcare Department

Moscow

E. Sidorova

MSU n.a. M.I. Lomonosov

Moscow

T. Rozina

SBEI HPE “First MSMU n.a.I.M.Sechenov" of RMPH

Moscow

E. Nikulkina

SBEI HPE “First MSMU n.a.I.M.Sechenov" of RMPH

Moscow

参考

  1. Бакулин И.Г., Галушко М.Ю. Противовирусная терапия хронического гепатита С: состояние вопроса. http://www.hcv.ru/
  2. Абдурахманов Д.Т., Морозов В.Г. Безопасность и эффективность телапревира в лечении хронического гепатита С у больных российской популяции, включенных в исследование по программе раннего доступа. РЖГГК. 2014;24(1):39-46.
  3. Manns M., Pol M., Jacobson I.M., et al. Alloral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study. Lancet 2014;384( 9954): 1597-605.
  4. Kao J-H., Heo J., Yoffe B., Sievert W., Jacobson I.M., Bessone F., Peng C-Y., Roberts S., Yoon K.T., Kopit J., Linaberry M., Noviello S., Hughes E., Manns M. Efficacy and safety of daclatasvir in combination with asunaprevir (DCV+ASV) in cirrhotic and non-cirrhotic patients with HCV genotype 1B: results of the the HALLMARK DUAL study. J. Hepatol. 2014;60(Suppl.):P1300.
  5. Kumada H., Suzuki Y., Ikeda K., Toyota J., Karino Y., Chayama K., Kawakami Y., Ido A., Yamamoto K., Takaguchi K., Izumi N., Koike K., Takehara T., Kawada N., Sata M., Miyagoshi H., Eley T., McPhee F., Damokosh A., Ishikawa H., Hughes E. Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology. 2014;59(6):2083-91.
  6. Wei L., Zhang M.X., еt al. Daclatasvir and Asunaprevir in Non-Japanese Asian Patients with Chronic HCV Genotype 1b Infection who are Ineligible for or Intolerant to Interferonalfa Therapies With or Without Ribavirin: Phase 2015;3 SVR12 Interim Results. ASLD.

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