METASTATIC GASTRIC CANCER: DESCRIPTION OF CLINICAL CASE


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详细

The emergence of drug tegafur+gimeracil+oteracil (TGO) - oral fluoropyrimidine derivative - provided a new look on the treatment of patients with metastatic gastric cancer. Interest in the drug is confirmed by the mass of international studies that examined its effectiveness in combination with various drugs. Combination of TGO with cisplatin was found to be as effective as the 5-FU and cisplatin (difference in median overall and progression-free survival were not statistically significant) with much less significant toxicity. The best safety profile allows to consider this drug as a promising medicine for the treatment of patients.

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作者简介

M. Abramov

FSBI “Russian Oncological Research Center n.a. N.N. Blokhin" of RMH PhD, Senior Researcher at the Department of Chemotherapy and Combined Therapy of Malignant Tumors FSBI «RORC n.a. N.N. Blokhin» of RMH Moscow

K. Bardovskaya

Moscow State University n.a. M.V. Lomonosov Moscow

A. Mescheryakov

FSBI “Russian Oncological Research Center n.a. N.N. Blokhin" of RMH Moscow

B. Medvedeva

FSBI “Russian Oncological Research Center n.a. N.N. Blokhin" of RMH Moscow

参考

  1. Globocan. Stomach cancer. Estimated incidence, mortlaity and prevalence worlwide http:// globocan.iarc.fr/old/FactSheets/cancers/ stomach-new.asp#INCIDENCE1.
  2. Sanford M. S-1 (Teysuno): A Review of Its Use in Advanced Gastric Cancer In Non-Asian Populations. Drugs 2013; 73(8):845-55.
  3. Ajani J., Rodrieguez W., Bodoky G., Moiseyenko V., Lichinitser M., Gorbunova V., Vynnychenko I., Garin A., Lang I., Falcon S. Multicenter Phase III Comparison of Cisplatin/S-1 With Cisplatin/ Infusional Fluorouracil in Advanced Gastric or Gastroesophageal Adenocarcinoma Study: The FLAGS Trial. J. Clin. Oncol. 2010;28(9): 1547-53.

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