Antibiotic-associated diarrhea: stratification of risk factors for development of Clostridium difficile infection in multidisciplinary hospital
- 作者: Zakharova N.V1, Fil T.S1
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隶属关系:
- FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMH
- 期: 编号 5S (2016)
- 页面: 60-64
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289739
- ID: 289739
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详细
The article presents the results of non-interventional prospective cohort study on the incidence of antibiotic-associated diarrhea (AAD) and assessment of risk factors for AAD in patients of multidisciplinary hospital. The structure of hospital-acquired AAD was analyzed. Diagnosis of Clostridium difficile toxins and highly virulent strains of this microorganism was performed by a two-step algorithm: enzyme immunoassay and real-time polymerase chain reaction. It was found that the AAD occurs against the background of antimicrobial therapy in 6.5% of cases. At the same time, C. difficile-associated diarrhea accounts for 50% of AAD cases. The following risk factors for C. difficile-associated AAD were identified: anemia, early postoperative period, hospitalization in the past six months, and antisecretory therapy.
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作者简介
N. Zakharova
FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMH
T. Fil
FSBEI HE “North-Western State Medical University n.a. I.I. Mechnikov" of RMH
Email: fts-88@mail.ru
Therapist, Postgraduate Student at the Department of Therapy and Clinical Pharmacology
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