Duodenogastroesophageal reflux and biliary pathology


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The literary review highlights modern ideas about the problem of duodenogastroesophageal reflux (DGR) in biliary pathology, in particular in persons who have undergone cholecystectomy. The article presents current data on the contribution of DGR to the pathogenesis of gastroesophageal reflux disease, Barrett’s esophagus and esophageal adenocarcinoma. Features of mechanisms of direct damaging action and cytokine-mediated damage of upper gastrointestinal mucosa by bile acids in refluxate are described. Diagnostic methods for detection of DGR are discussed, particular attention is paid to the principles of treatment of patients with this condition.

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作者简介

Yu. Uspensky

St. Petersburg State Pediatric Medical University; Pavlov University

Email: uspenskiy65@mail.iu
St. Petersburg, Russia

Yu. Fominykh

St. Petersburg State Pediatric Medical University; Pavlov University

St. Petersburg, Russia

A. Gnutov

St. Petersburg State Pediatric Medical University

St. Petersburg, Russia

V. Filippova

St. Petersburg State Pediatric Medical University

St. Petersburg, Russia

参考

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