The influence of CYP2C9 gene polymorphisms on the efficacy of losartan in patients with grade I-II arterial hypertension
- 作者: Sinitsina I.I1, Boyarko A.V2, Temirbulatov I.I1, Mirzaev K.B1, Grishina E.A1, Sozaeva Z.A1, Akmalova K.A1, Shuev G.N1, Denisenko N.P1, Kachanova A.A1, Sychev D.A1
-
隶属关系:
- Russian Medical Academy of Continuous Professional Education
- LMS Clinic
- 期: 卷 28, 编号 3 (2021)
- 页面: 57-61
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313104
- DOI: https://doi.org/10.18565/pharmateca.2021.3.57-61
- ID: 313104
如何引用文章
详细
全文:
![受限制的访问](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
作者简介
I. Sinitsina
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
A. Boyarko
LMS ClinicMoscow, Russia
Ilyas Temirbulatov
Russian Medical Academy of Continuous Professional Education
Email: temirbulatov.ilyas@gmail.com
Resident at the Department of Clinical Pharmacology and Therapy Moscow, Russia
K. Mirzaev
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
E. Grishina
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
Zh. Sozaeva
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
K. Akmalova
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
G. Shuev
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
N. Denisenko
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
A. Kachanova
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
D. Sychev
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
参考
- Turner S.T., Schwartz G.L., Chapman A.B., et al. Antihypertensive pharmacogenetics: Getting the right drug into the right patient. J Hypertens. 2001;19:1-11.
- Williams B., Mancia G., Spiering W., et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur. Heart J. 2018;39:3021-104. doi: 10.1093/eurheartj/ehy339.
- Suchard M.A., Schuemie M.J., Krumholz H.M., et al. Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis. Lancet. 2019;394:1816-26. doi: 10.1016/S0140-6736(19)32317-7.
- Sica D.A., Gehr T.W.B., Ghosh S. Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44:797-814. doi: 10.2165/00003088-200544080-00003.
- Spiering W., Kroon A.A., Fuss-Lejeune M.J.M.J., De Leeuw PW. Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade. J. Hypertens. 2005;23:753-58. doi: 10.1097/01. hjh.0000163143.66965.06.
- Yasar U., Tybring G., Hidestrand M., et al. Role of Cyp2C9 Polymorphism in Losartan Oxidation. Drug Metab Dispos.2001;29:1051-56.
- Wang B., Wang J., Huang S.-Q., et al. Genetic Polymorphism of the Human Cytochrome P450 2C9 Gene and Its Clinical Significance. Curr Drug Metab. 2009;10:781-834. doi: 10.2174/138920009789895480.
- Yasar U., Forslund-Bergengren C., Tybring G., et al. Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype. Clin Pharmacol Ther. 2002;71:89-98. doi: 10.1067/mcp.2002.121216.
- Zhou Y., Ingelman-Sundberg M., Lauschke V.M. Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. Clin Pharmacol Ther. 2017;102:688-700. doi: 10.1002/cpt.690.
- Мирзаев К.Б., Федоринов Д.С., Иващенко Д.В., Сычев Д.А. Мультиэтнический анализ кардиологических фармакогенетических маркеров генов цитохрома Р450 и мембранных транспортеров в российской популяции. Рациональная фармакотерапия в кардиологии. 2019;15(3):393-406
- Cabaleiro T., Roman M., Ochoa D., et al. Evaluation of the relationship between sex, polymorphisms in CYP2C8 and CYP2C9, and pharmacokinetics of angiotensin receptor blockers. Drug Metab. Dispos. 2013;41:22429. doi: 10.1124/dmd.112.046292
- Yasar Ü., Dahl M.L., Christensen M., Eliasson E. Intraindividual variability in urinary losartan oxidation ratio, an in vivo marker of CYP2C9 activity. Br. J. Clin. Pharmacol. 2002;54:183-85.
- Sekino K., Kubota T., Okada Y., et al. Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects. Eur J Clin Pharmacol 2003;59:589-92. doi: 10.1007/s00228-003-0664-5.
- Joy M.S., Dornbrook-Lavender K., Blaisdell J., et al. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Eur. J. Clin. Pharmacol. 200965:947-53. doi: 10.1007/s00228-009-0707-7.
- de Andres F., Teran S., Bovera M., et al. Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach. OMICS. 2016;20:88-96. Doi: 10.1089/ omi.2015.0131.
- Сычев Д.А. Рекомендации для фармацевтических компаний по изучению биотрансформации и транспортеров новых лекарственных средств: дизайн исследований, анализ данных и внесение информации в инструкции по применению. Науч. ред. В.Г. Кукес. М., 2009
- Parati G., Stergiou G., O'Brien E., et al. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring. J Hypertens. 2014;32:1359-66. doi: 10.1097/HJH.0000000000000221.
- Gaborieau V., Delarche N., Gosse P Ambulatory blood pressure monitoring versus self-measurement of blood pressure at home: Correlation with target organ damage. J. Hypertens. 2008;26:1919-27. doi: 10.1097/HJH.0b013e32830c4368.
- Clement D.L., De Buyzere M.L., De Bacquer D.A., et al. Prognostic Value of Ambulatory Blood-Pressure Recordings in Patients with Treated Hypertension. N Engl J Med. 2003;348:2407-15. Doi: 10.1056/ nejmoa022273.
- Banegas J.R., Ruilope L.M., de la Sierra A., et al. Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality. N Engl J Med. 2018;378:1509-20. doi: 10.1056/nejmoa1712231.
- Sega R., Facchetti R., Bombelli M., et al. Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: Follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Circulation. 2005;111:1777-83. doi: 10.1161/01. CIR.0000160923.04524.5B.
补充文件
![](/img/style/loading.gif)