Manifestation of primary adrenal insufficiency in a child against the background of a novel coronovirus infection COVID-19: a clinical case
- 作者: Zhurtova I.B.1, Elgarova M.A1, Gubachikova A.M1, Kurashinova M.R1
-
隶属关系:
- Kabardino-Balkarian State University n.a. Kh.M. Berbekov
- 期: 卷 29, 编号 1 (2022)
- 页面: 90-95
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/320950
- DOI: https://doi.org/10.18565/pharmateca.2022.1.90-95
- ID: 320950
如何引用文章
详细
Background. Primary adrenal insufficiency (PAI) is a disease characterized by decreased production of adrenal hormones. As a rule, this term refers to various variants of hypocorticism vary in etiology and pathogenesis. In childhood, in terms of genesis, hereditary syndromes prevail, in which adrenal insufficiency (AI) with a gradual onset and slow progression is diagnosed. Gastrointestinal disorders - loss of appetite, nausea, vomiting - are sometimes observed already at the onset of the disease and necessarily occur with an augmentation of AI. Description of the clinical case. The article deals with a clinical case of PAI in a child of 11 years old, which manifested itself against the background of a novel coronovirus infection COVID-19. Conclusion. Most symptoms of cortisol and aldosterone deficiency are nonspecific and may be a sign of diseases of other organs and systems (gastrointestinal tract, central nervous system, etc.). Diagnostic search for a specific nosological form of AI allows predicting the course of the disease, the likelihood of the appearance of pathology in other organs and systems, and determining the tactics of management of the patient.
全文:
![受限制的访问](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
作者简介
Inessa Zhurtova
Kabardino-Balkarian State University n.a. Kh.M. Berbekov
Email: zhin07@mail.ru
Dr. Sci. (Med.), Professor at the Department of Faculty Therapy Nalchik, Russia
M. Elgarova
Kabardino-Balkarian State University n.a. Kh.M. BerbekovNalchik, Russia
A. Gubachikova
Kabardino-Balkarian State University n.a. Kh.M. BerbekovNalchik, Russia
M. Kurashinova
Kabardino-Balkarian State University n.a. Kh.M. BerbekovNalchik, Russia
参考
- Husebye E.S., Pearce S.H., Krone N.P, K mpe O. Adrenal insufficiency Lancet. 2021;397(10274):613-29. Doi: 10.1016/ S0140-6736(21)00136-7.
- Kirkgoz T., Guran T. Primary adrenal insufficiency in children: Diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2018;32(4):397-424. doi: 10.1016/j.beem.2018.05.010.
- Орлова Е.М. Хроническая надпочечниковая недостаточность у детей: ранняя диагностика и лечение в группах риска. Доктор. ру 2009;6-2(50):50-4.
- Иванова М.З., Журтова И.Б., Сижажева С.Х., Губачикова А.М. Предикторы тяжелого течения заболевания и высокой летальности у пациентов с COVID-19 и сахарным диабетом. Фарматека. 2021;28(4):10-5. Doi: 10.18565/ pharmateca.2021.4.10-15.
- Perez-Saez J., et al. Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland. Lancet. Infect Dis. 2020;S1473-3099(20)30584-3. doi: 10.1016/S1473-3099(20)30584-3.
- Лобанова М.В., Максимова Т.В., Ванькович Е.А. Первичная хроническая надпочечнико вая недостаточность на фоне аутоиммунного полигландулярного синдрома. Военная медицина. 2019;3:143-48.
- Auron M., Raissouni N. Adrenal insufficiency Pediatr Rev. 2015;36(3):92-102. Doi: 10.1542/ pir.36-3-92.
- URL: http://www.rare-diseases.ru/rare-diseases/encyclopediadiseases/122-2010-07-03-18-27-20.
- Zhu J., Eichler F, Biffi A., et al. The Changing Face of Adrenoleukodystrophy. Endocr Rev. 2020;41(4):577-93. doi: 10.1210/endrev/bnaa013.
- OMIM: An online catalog of human genes and genetic disorders [Electronic resource]. Electronic data. Bal-timore: Johns Hopkins Univ. 2015. Mode of access: URL: http://www.omim.org/
- Emmett M., Sterns R.H., Forman J.P Bartter and Gitelman syndromes [Electronic resource]. UpToDate. Electronic data, 2015; mode of access: URL: http://www.uptodate.com/contents/bartter-and-gitelman syndromes
- Allgrove J., Clayden G.S., Grant D.B., Macaulay J.C. Familial glucocorticoid deficiency with achalasia of the cardia and deficient tear production. Lancet. 1978;1(8077):1284-86. doi: 10.1016/s0140-6736(78)91268-0
- Волкова Н.И., Давиденко И.Ю., Решетников И.Б., Бровкина С.С. Синдром Оллгрова: как заподозрить проблему? Опыт эндокринолога. Проблемы эндокринологии. 2020;66(1):64-9. doi: 10.14341/probl10296.
- Thomas J., Subramanyam S., Vijayaraghavan S., Bhaskar E. Late onset adrenal insufficiency and achalasia in Allgrove syndrome. BMJ. Case Rep. 2015;bcr2014208900. doi: 10.1136/bcr-2014-208900.
- Patt H., Koehler K., Lodha S., et al. Phenotype-genotype spectrum of AAA syndrome from Western India and systematic review of literature. Endocr Connect. 2017;6(8):901-13. doi: 10.1530/EC-17-0255.
- Tibussek D., Ghosh S., Huebner A., et al. «Crying without tears» as an early diagnostic sign-post of triple A (Allgrove) syndrome: two case reports. BMC. Pediatr. 018;18(1):6. Doi: 10.1186/ s12887-017-0973.
- Brown B., Agdere L., Muntean C., David K. Alacrima as a harbinger of adrenal insufficiency in a child with Allgrove (AAA) syndrome. Am J Case Rep. 2016;17:703-6. doi: 10.12659/ajcr.899546.
- Arlt W., Baldeweg S.E., Pearce S.H.S., Simpson H.L. Endocrinology in the time of COVID-19: Management of adrenal insufficiency. Eur J Endocrinol. 2020;183(1):G25-32. doi: 10.1530/EJE-20-0361.
补充文件
![](/img/style/loading.gif)