Algorithm for diagnostics and systemic therapy of metastatic hormone-sensitive HER2-negative breast cancer

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Modern methods of systemic therapy of metastatic breast cancer (mBC) include the use of various combinations of chemotherapy, hormonal therapy, targeted and immunotherapy. The development and introduction of new therapeutic agents continue to change the standards of treatment and open new horizons for an individualized approach to therapy. This article considers the features of diagnostics, available treatment options for hormone-sensitive HER2-negative mBC and promising new treatment methods.

全文:

受限制的访问

作者简介

Garik Dashyan

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

编辑信件的主要联系方式.
Email: dgarik@mail.ru
ORCID iD: 0000-0001-6183-9764
SPIN 代码: 6989-7148

Dr. Sci. (Med.), Oncologist, Head of the oncology department No. 1

俄罗斯联邦, St. Petersburg

A. Olchonova

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0009-0007-3112-8081
SPIN 代码: 6144-1590
俄罗斯联邦, St. Petersburg

E. Dzhelyalov

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0002-2571-243X
SPIN 代码: 7261-2325
俄罗斯联邦, St. Petersburg

R. Akhmedov

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0003-3348-4251
SPIN 代码: 5361-5059
俄罗斯联邦, St. Petersburg

O. Sereda

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0001-7553-2026
俄罗斯联邦, St. Petersburg

A. Vats

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0009-0000-0450-0166
俄罗斯联邦, St. Petersburg

A. Zhurov

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0009-0004-7511-2952
俄罗斯联邦, St. Petersburg

L. Shaikhelislamova

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0001-9623-3877
SPIN 代码: 2166-8716
俄罗斯联邦, St. Petersburg

G. Pushkaruk

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0009-0000-8348-0633
俄罗斯联邦, St. Petersburg

A. Belousov

N.I. Pirogov Clinic of High Medical Technologies, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0002-2274-8170
SPIN 代码: 2842-7325
俄罗斯联邦, St. Petersburg

参考

  1. World Health Organization (WHO). Breast Cancer. WHO; 2021. Accessed April 18, 2022. URL: https://www.who.int/news-room/fact-sheets/detail/breast-cancer.
  2. Daily K., Douglas E., Romitti P.A., Thomas A. Epidemiology of de novo metastatic breast cancer. Clin Breast Cancer. 2021;21(4):302–8. doi: 10.1016/j.clbc.2021.01.017.
  3. Criscitiello C., André F., Thompson A.M., et al. Biopsy confirmation of metastatic sites in breast cancer patients: clinical impact and future perspectives. Breast Cancer Res. 2020;16(2):205. doi: 10.1186/bcr3630.
  4. Ma C.X., Sparano J.A. Treatment for hormone receptor-positive, HER2-negative advanced breast cancer UpToDate. 2024.
  5. Cardoso F., Paluch-Shimon S., Schumacher-Wulf E., et al. 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7). Breast. 2024;76:103756. doi: 10.1016/j.breast.2024.103756.
  6. Gabe S. Sonke, et al. Primary outcome analysis of the phase 3 SONIA trial (BOOG 2017-03) on selecting the optimal position of CDK4/6 inhibitors for patients with HR+, HER2 advanced breast cancer (ABC); Meeting Abstract LBA1000, 2023 ASCO Annual Meeting.
  7. Yan Y., Wu B., Wang L. A real-world pharmacovigilance study of QT interval prolongation and Torsades de Pointes associated with CDK4/6 inhibitors in breast cancer patients: findings from the FDA adverse event reporting system. Expert Opin Drug Saf. 2024;23(9):1191–8. doi: 10.1080/14740338.2024.2307375.
  8. Tripathy D., Im S.A., Colleoni M., et al. Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial. Lancet Oncol. 2018;19(7):904–15. doi: 10.1016/S1470-2045(18)30292-4.
  9. Gelmon K., Walshe J.M., Mahtani R., et al. Efficacy and safety of palbociclib in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with preexisting conditions: A post hoc analysis of PALOMA-2. Breast. 2021;59:321–6. doi: 10.1016/j.breast.2021.07.017.
  10. Goetz M.P., Toi M., Campone M., et al. MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer. J Clin Oncol. 2017;35(32):3638–46. doi: 10.1200/JCO.2017.75.6155. [Epub 2017 Oct 2, PMID: 28968163].
  11. Singh S. Review on Natural Agents as Aromatase Inhibitors: Management of Breast Cancer. Comb Chem High Throughput Screen. 2024;27(18):2623–38. doi: 10.2174/0113862073269599231009115338.
  12. Turner N.C., Ro J., Andre F., et al.; PALOMA3 Study Group. Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer. N Engl J Med. 2015;373(3):209–19. doi: 10.1056/NEJMoa1505270.
  13. Llombart-Cussac A., Perez-Garcia J.M., Bellet M., et al.; PARSIFAL Steering Committee and Trial Investigators. Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor-Positive, ERBB 2-Negative Advanced Breast Cancer: A Randomized Clinical Trial. JAMA Oncol. 2021;7(12):1791–9. doi: 10.1001/jamaoncol.2021.4301.
  14. Cristofanilli M., Turner N.C., Bondarenko I., et al. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol. 2016;17(4):425–39. doi: 10.1016/S1470-2045(15)00613-0.
  15. Andrade M.O., Bonadio R.R.D.C.C., Diz M.D.P.E., Testa L. Visceral crisis in metastatic breast cancer: an old concept with new perspectives. Clinics (Sao Paulo). 2024;79:100362. doi: 10.1016/j.clinsp.2024.100362.
  16. Mogrovejo E., Manickam P., Amin M., Cappell .S. Characterization of the syndrome of acute liver failure caused by metastases from breast carcinoma. Dig Dis Sci. 2014;59(4):724–36. doi: 10.1007/s10620-013-2943-z.
  17. Sbitti Y., Slimani K., Debbagh A., et al. Visceral Crisis Means Short Survival Among Patients With Luminal A Metastatic Breast Cancer: A Retrospective Cohort Study. World J Oncol. 2017;8(4):105–9. doi: 10.14740/wjon1043w.
  18. Franzoi M.A., Saude-Conde R., Ferreira S.C., et al. Clinical outcomes of platinum-based chemotherapy in patients with advanced breast cancer: An 11-year single institutional experience. Breast. 2021;57:86–94. doi: 10.1016/j.breast.2021.03.002.
  19. Lu Y.S., Mahidin E.I.B.M., Azim H., et al. Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Versus Combination Chemotherapy in Premenopausal Women With Clinically Aggressive Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer. J Clin Oncol. 2024;42(23):2812–21. doi: 10.1200/JCO.24.00144.
  20. Modi S., Jacot W., Yamashita T., et al. Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer. N Engl J Med. 2022;387(1):9–20. doi: 10.1056/NEJMoa2203690.
  21. Rugo H.S., Bardia A., Marme F., et al. Sacituzumab govitecan in hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2022;40(29):3365–76. doi: 10.1200/JCO.22.01002.
  22. Saatci O., Huynh-Dam K.T., Sahin O. Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies. J Mol Med (Berl). 2021;99(12):1691–710. doi: 10.1007/ s00109-021-02136-5.
  23. Rasha F., Sharma M., Pruitt K. Mechanisms of endocrine therapy resistance in breast cancer. Mol Cell Endocrinol. 2021;532:111322. doi: 10.1016/j.mce.2021.111322.
  24. Toy W., Shen Y., Won H., et al. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet. 2013;45(12):1439–45. doi: 10.1038/ng.2822.
  25. Andre F., Ciruelos E., Rubovszky G., et al.; SOLAR-1 Study Group. Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer. N Engl J Med. 2019;380(20):1929–40. doi: 10.1056/NEJMoa1813904.
  26. Howell S.J., Casbard A., Carucci M., et al. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. Lancet Oncol. 2022;23(7):851–64. doi: 10.1016/S1470-2045(22)00284-4.
  27. Robson M., Im S.A., Senkus E., et al. Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. N Engl J Med. 2017;377(6):523–33. doi: 10.1056/NEJMoa1706450.
  28. Oliveira M., Rugo H.S., Howell S.J., et al.; CAPItello-291 study group. Capivasertib and fulvestrant for patients with hormone receptor-positive, HER2-negative advanced breast cancer (CAPItello-291): patient-reported outcomes from a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2024;25(9):1231–44. doi: 10.1016/S1470-2045(24)00373-5.
  29. Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61.
  30. Ogitani Y., Aida T., Hagihara K., et al. DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1. Clin Cancer Res. 2016;22:5097–108.
  31. Ogitani Y., Hagihara K., Oitate M., et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016;107:1039–46.
  32. Modi S., Jacot W., Yamashita T., et al. Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer. N Engl J Med. 2022;387:9.
  33. Litton J.K., Rugo H.S., Ettl J., et al. Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation. N Engl J Med. 2018;379(8):753–63. doi: 10.1056/NEJMoa1802905.
  34. Chan S., Friedrichs K., Noel D., et al. Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer. J Clin Oncol. 1999;17(8):2341–54.
  35. Paridaens R., Biganzoli L., Bruning P., et al. Paclitaxel versus doxorubicin as first-line single-agent chemotherapy for metastatic breast cancer: a European Organization for Research and Treatment of Cancer Randomized Study with cross-over. J Clin Oncol 2000;18(4):724–33.
  36. Jones S.E., Erban J., Overmoyer B., et al. Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J. Clin Oncol. 2005;23(24):5542–51.
  37. Mauri D., Kamposioras K., Tsali L., et al. Overall survival benefit for weekly vs. three-weekly taxanes regimens in advanced breast cancer: A meta-analysis. Cancer Treat Rev. 2010;36(1):69–74. doi: 10.1016/j.ctrv.2009.10.006. [Epub 2009 Nov 27, PMID: 19945225].
  38. Cortes J., O’Shaughnessy J., Loesch D., et al. Eribulin monotherapy versus treatment of physician’s choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study. Lancet 2011;377(9769):914–23.
  39. Kaufman P.A., Awada A., Twelves C., et al. Phase III open-label randomized study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2015;33(6):594–601.
  40. Pflumio C., Carton M., Debled M., et al. Is Capecitabine the best treatment option for estrogen receptor-positive HER2-negative metastatic breast cancer after progression on endocrine treatment: an analysis of the ESME real-world database. ESMO 2024.
  41. Rugo H.S., Bardia A., Marmé F., et al. Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial. Lancet. 2023;402:1423.

补充文件

附件文件
动作
1. JATS XML
下载
2. Fig. Therapeutic algorithm for hormone-sensitive metastatic breast cancer

下载 (565KB)
索引源数据

版权所有 © Bionika Media, 2024