Efficiency of human placenta extract as a subcutaneous injection in patients with uterine factor of infertility in ART programs

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Background: The problem of infertility and implantation failures in ART programs is widespread in Russia and the world. The development of medicine and directly methods of assisted reproductive technologies (ART) have had a positive effect on the effectiveness of IVF programs, but the percentage of unsuccessful implantations remains high. The contribution of chronic endometritis as a uterine factor of infertility, reducing the percentage of pregnancy, is underestimated; there is no general concept for managing patients with this diagnosis.

Objective: Evaluation and justification of the effectiveness of complex treatment, including peptide therapy, in patients with chronic endometritis associated with ART programs.

Results: In this study, we substantiated the effectiveness of a comprehensive treatment algorithm for patients and described the contribution of human placenta extract to ART programs with infertility and a confirmed diagnosis of chronic endometritis.

Conclusion: The proposed treatment algorithm for patients with chronic endometritis associated with ART programs, including a combination of physiotherapy and peptide therapy with Melsmon, increases the pregnancy rate in cryopreservation cycles of euploid embryos to 73% and can be recommended for the treatment of uterine infertility.

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作者简介

Stanislava Kuzina

GC Mother and Child, Lapino Clinical Hospital

编辑信件的主要联系方式.
Email: stasy83@bk.ru
ORCID iD: 0009-0006-9859-0003

Obstetrician-Gynecologist

俄罗斯联邦, Moscow

Elena Silantyeva

GC Mother and Child, Lapino Clinical Hospital

Email: stasy83@bk.ru
ORCID iD: 0000-0002-7667-3231
俄罗斯联邦, Moscow

Maria Ovchinnikova

GC Mother and Child, Lapino Clinical Hospital

Email: stasy83@bk.ru
ORCID iD: 0000-0002-3424-1721
俄罗斯联邦, Moscow

Yulia Kutakova

GC Mother and Child, Lapino Clinical Hospital

Email: stasy83@bk.ru
ORCID iD: 0000-0002-4273-4788
俄罗斯联邦, Moscow

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2. Figure 1. Dynamics of complaints after treatment

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3. Figure 2. The effectiveness of pregnancy in ART programs

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