The level of uric acid and its role at early stages of essential hypertension


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Abstract

Aim: correlation of uric acid (UA) level on serum blood and urine with indicators of not specific inflammation and clinical
characteristic in essential hypertension (EH) patients. Methods: 67 patients with EH (48 men) 30-65 years age (442) with
stage 1 EH (n=37) and 2 (n=30) with moderate or high cardiovascular (CV) risk. The control group - 14 healthy peoples: (6
men) 45,52,1 years age with normal blood pressure (BP). The normal level of С-reactive protein (CRP) is less 3 mg/l. The
normal level of UA in blood is 202,3-416,5 mkmol/l, and in urine is 1,48-4,43 mmol/24 hour. The estimates of creatinine
clearance by the Cockroft-Gault formula. Results: the patients with EH have bigger level CRP, UA in blood and urine than
healthy peoples with normal BP. Higher levels UA in blood and urine have patients even with early stages EH and moderate
CV risk. The bigger level of UA in blood has EH patients with obesity and dyslipidaemia. The level of UA in blood and urine is
higher at EH patients with hyperfiltration vs patients with normal creatinine clearance. Conclusion: the patients with early
stage of EH have higher level of UA in blood and urine than healthy peoples with normal BP. The level of UA in blood and
urine is correlated with dyslipidaemia. Key words: essential hypertension, uric acid, non specific inflammation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 83918 от 12.09.2022 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 83917 от 12.09.2022 г.


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