Protein Ki-67 and collagen iv in diagnosis in prostatic neoplasms

Aim. Assessment of prostatic expression of protein KI-67 and collagen IV in benign prostatic hyperplasia and prostatic cancer. Methods. Specimes of prostatic tissue of 53 patients (age 52-83 years) with prostatic adenocarcinoma and 10 -with benign prostatic hyperplasia were analysed. All patients were BIOPSIED in 2010-2014 years. Results. High expression of collagen IV was found in benign prostatic hyperplasia, in prostatic adenocarcinoma expression of collagen IV was low. Glisson scale stage corellated with cell proliferation index according to KI-67 expression (rs =0,674). Conclusion. Measurement of KI-67 expression can be used in differential diagnosis between benign prostatic hyperplasia and prostatic adenocarcinoma.

Ki-67 protein, collagen iv, prostatic adenocarcinoma, expression