Diagnosis and principles of therapy of multiple myeloma
- Авторлар: Semochkin S.V1,2
-
Мекемелер:
- FSB El HE "N.I. Pirogov Russian National Research Medical University" of RMH, Department of Oncology, Hematology and Radiation Therapy
- SBHCI "City Clinical Hospital № 52 of the Moscow Healthcare Department"
- Шығарылым: № 2 (2018)
- Беттер: 15-22
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/272760
- DOI: https://doi.org/10.18565/nephrology.2018.2.15-22
- ID: 272760
Дәйексөз келтіру
Аннотация
MULTIPLE MYELOMA (MM) IS A MALIGNANT TUMOR CHARACTERIZED BY BONE MARROW INFILTRATION WITH CLONAL PLASMA CELLS AND THE SECRETION OF MONOCLONAL IMMUNOGLOBULIN DETECTED IN SERUM AND/OR URINE. MORPHOLOGICAL VERIFICATION ASSUMES THE NEED TO DIAGNOSE >10% OF CLONAL PLASMOCYTES IN BONE MARROW ASPIRATE OR CONFIRMATION BY HISTOLOGICAL EXAMINATION OF THE PLASMACYTOMA BIOPSY SAMPLE. IN ADDITION, ONE OR MORE EVENTS THAT DETERMINE THE MYELOMA, INCLUDING CRAB SYMPTOMS, IS NECESSARY, OR ANY MARKER OF BIOLOGICAL MALIGNANCY (≥60% OF CLONAL PLASMA CELLS IN THE BONE MARROW; THE RATIO BETWEEN INVOLVED AND UNINVOLVED FREE LIGHT CHAINS OF IMMUNOGLOBULINS [FLC] ≥100; OR THE PRESENCE OF MORE THAN ONE LYTIC FOCUS ACCORDING TO MRI DATA). SYMPTOMATIC MM IS PRECEDED BY PRE-MALIGNANT STAGES, SUCH AS MONOCLONAL GAMMAPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) AND SMOLDERING MULTIPLE MYELOMA (SMM), WHICH DO NOT REQUIRE TREATMENT. IN THE LAST DECADE, SIGNIFICANT PROGRESS HAS BEEN NOTED IN THE INDIVIDUALIZATION OF THERAPY FOR PATIENTS WITH MM. HIGH-DOSE CHEMOTHERAPY FOLLOWED BY AUTO HEMOPOLETIC STEM CELL TRANSPLANTATION (AUTOHSCT) IS CRITICALLY IMPORTANT. NEW CLASSES OF DRUGS, SUCH AS PROTEASOME INHIBITORS (BORTEZOMIB) AND IMMUNOMODULATORS (LENALIDOMIDE), ARE INCLUDED IN MODERN INDUCTION REGIMENS THAT PRECEDE TRANSPLANTATION. AFTER AUTOHSCT, PATIENTS WITH STANDARD RISK ARE TREATED WITH MAINTENANCE THERAPY USING LENALIDOMIDE, IN CASE OF HIGH RISK - USING BORTEZOMIB. PATIENTS WHO ARE NOT CONSIDERED AS CANDIDATES FOR AUTOHSCT GAIN THE MAXIMUM BENEFIT FROM LENALIDOMIDE-CONTAINING THERAPY (RD SCHEME), WHICH IS CARRIED OUT UNTIL PROGRESSION. THE ALTERNATIVE IS BORTEZOMIB-CONTAINING VD AND VMP REGIMENS.
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Авторлар туралы
S. Semochkin
FSB El HE "N.I. Pirogov Russian National Research Medical University" of RMH, Department of Oncology, Hematology and Radiation Therapy; SBHCI "City Clinical Hospital № 52 of the Moscow Healthcare Department"
Email: s.semochkin@gmail.com
Doctor of Medical Sciences, Prof at the Department of Oncology, Hematology and Radiation Therapy; Hematologist
Әдебиет тізімі
- Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015; 136(5): E359-E386. doi: 10.1002/ijc.29210.
- Kazandjian D. Multiple myeloma epidemiology and survival: A unique malignancy. Semin. Oncol. 2016; 43(6): 676-681. doi: 10.1053/j.seminoncol.2016.11.004.
- Rosenberg PS., Barker K.A., Anderson WF Future distribution of multiple myeloma in the United States by sex, age, and race/ethnicity. Blood. 2015; 125(2): 410-412. doi: 10.1182/blood-2014-10-609461.
- Yamabe K., Inoue S., Hiroshima C. Epidemiology and Burden of Multiple Myeloma in Japan: a Systematic Review. Value Health. 2015; 18(7): A449. doi: 10.1016/j.jval.2015.09.1129
- Злокачественные новообразования в России в 2016 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2018. 250 с.
- Менделеева Л.П., Вотякова О.М., Покровская О. С., и др. Национальные клинические рекомендации по диагностике и лечению множественной миеломы. Гематология и трансфузиология. 2016; 61(l,S2): l-24.
- Luchinin A.S., Semochkin S.V., Minaeva N.V., et al. Epidemiology and Analysis of Early Mortality of Patients with Multiple Myeloma in Russia According to the Kirov Regional Population-Based Database. Blood. 2017; 130: 5382.
- Kyle R.A., Larson D.R., Therneau TM., et al. Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance. N. Engl. J. Med. 2018; 378(3): 241-249. doi: 10.1056/NEJMoal709974.
- Muchtar E., Kumar S.K., Magen H., Gertz M.A. Diagnosis and management of smoldering multiple myeloma: the razor’s edge between clonality and cancer. Leuk. Lymphoma. 2018; 59(2): 288-299. doi: 10.1080/10428194.2017.1334124.
- Rajkumar S. V., Dimopoulos M.A., Palumbo A., et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014; 15(12): e538-e548.
- Rajkumar S.V., Larson D., Kyle R.A. Diagnosis of smoldering multiple myeloma. N. Engl. J. Med. 2011; 365(5): 474-475. doi: 10.1056/NEJMcl106428.
- Kastritis E., Terpos E., Moulopoulos L., Spyropoulou-Vlachou M., Kanellias N., Eleftherakis-Papaiakovou E., Gkotzamanidou M., Migkou M., Gavriatopoulou M., Roussou M., Tasidou A., Dimopoulos M.A. Extensive bone marrow infiltration and abnormal free light chain ratio identifies patients with asymptomatic myeloma at high risk for progression to symptomatic disease. Leukemia. 2013; 27(4): 947-953. doi: 10.1038/leu.2012.309.
- Larsen J.T., Kumar S.K., Dispenzieri A., Kyle R.A., Katzmann J.A., Rajkumar S.V. Serum free light chain ratio as a biomarker for highrisk smoldering multiple myeloma. Leukemia. 2013; 27(4): 941-946. doi: 10.1038/leu2012.296.
- Hillengass J., Eechtner K., Weber M.A., Bäuerle T., Ayyaz S., Heiss C., Hielscher T., Moehler TM., Egerer G., Neben K., Ho A.D., Kauczor H.U., Delorme S., Goldschmidt H. Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma. J. Gin. Oncol. 2010; 28(9): 1606-1610. doi: 10.1200/JCO.2009.25.5356
- Kastritis E., Moulopoulos L.A., Terpos E., Koutoulidis V., Dimopoulos M.A. The prognostic importance of the presence of more than one focal lesion in spine MRI of patients with asymptomatic (smoldering) multiple myeloma. Leukemia. 2014; 28(12/2402-2403. doi: 10.1038/leu.2014.230.
- Regelink J.C., Minnema M.C., Terpos E., et al. Comparison of modern and conventional imaging techniques in establishing multiple myeloma-related bone disease: a systematic review. Br. J. Haematol. 2013; 162(1): 50-61. doi: 10.1111/bjh.12346.
- Dimopoulos M.A., Sonneveld P., Leung N., et al. International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment. J. Clin. Oncol. 2016; 34(13): 1544- 1557. doi: 10.1200/JCO.2015.65.0044.
- Grammatico S., Scalzulli E., Petrucci M.T. Solitary Plasmacytoma. Mediterr. J. Hematol. Infect. Dis. 2017; 9(l): e2017052. Doi: 10.4084/ MJHID.2017.052.
- Caers J., Paiva B., Zamagni E., et al. Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J. Hematol. Oncol. 2018; 11(1): 10. doi: 10.1186/si3045-017-0549-1.
- Sonneveld P., Avet-Loiseeau H., Lonila S., et al. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Blood. 2016; 127(24): 2955-2962. doi: 10.1182/blood-2016-01-631200.
- Лучинин A.C., Семочкин C.B., Минаева H.В., и др. Эволюция противоопухолевой терапии и ее влияние на суррогатные факторы прогноза множественной миеломы. Клиническая онкогематология. 2018; 11(2): 175-181.
- Chan N.C., Chan N.P. Recurrent Cytogenetic Abnormalities in Multiple Myeloma. Methods Mol. Biol. 2017; 1541: 295-302. doi: 10.1007/978-1-4939-6703-2J23.
- Palumbo A., Avet-Loiseau H., Oliva S., et al. Revised International Staging System for multiple myeloma: a report from International Myeloma Working Group. J. Gin. Oncol. 2015; 33(26): 2863-2869. doi: 10.1200/JCO.2015.61.2267.
- Moreau P., San Miguel J., Sonneveld P., et al. Multiple myeloma: ESMO Ginical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2017; 28(4): iv52-iv61. doi: 10.1093/annonc/mdx096.
- Attal М., Lauwers-Cances V., Hulin С., et al. Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma. N. Engl. J. Med. 2017; 37б(14): 1311-1320. doi: 10.1056/NEJMoal611750.
- McCarthy P., Holstein S. Role of stem cell transplant and maintenance therapy in plasma cell disorders. Hematology. 2016; 2016: 504-511. doi: 10.1182/asheducation-2016.1.504.
- McCarthy P.L., Holstein S.A., Petrucci M. T. et al. Lenalidomide Maintenance After Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: A Meta-Analysis. J. Clin. Oncol. 2017; 35(29): 3279-3289.
- Само М., Gay F.M., Patriarca F., et al. Double autologous stem cell transplantation significantly prolongs progression-free survival and overall survival in comparison with single autotransplantation in newly diagnosed multiple myeloma: an analysis of phase 3 EMN02/H095 study. Blood. 2017; 130: 401.
- Stadtmauer E.A., Pasquini M.C., Blackwell В., et al. Comparison of autologous hematopoietic cell transplant (autoHCT), bortezomib, lenalidomide (len) and dexamethasone (RVD) consolidation with len maintenance (ACM), tandem autohct with len Maintenance (TAM) and autohct with len maintenance (AM) for up-front treatment of patients with multiple myeloma (MM): primary results from the randomized phase III trial of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0702 - StaMINA Trial). Blood. 2016; 128(22): Abstract LBA-1.
- Façon T., Dimopoulos M.A., Dispenzieri A., et al. Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma. Blood. 2018; 131(3): 301-310. doi: 10.1182/blood-2017-07795047.
- Mateos M.V., Martinez-López I., Hernandez M.T., et al. Sequential vs alternating administration of VMP and Rd in elderly patients with newly diagnosed MM. Blood. 2016; 127(4): 420-425. doi: 10.1182/blood-201508-666537.
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