Distribution of HLA-antigens among patients with chronic kidney disease


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Introduction. HLA-complex causes a genetic predisposition to a number of diseases or, con-versely, is associated with resistance to certain diseases. Objective. Evaluation of the distribution of antigen genetic polymorphism, histocompatibility of patients with end-stage renal disease and donors (healthy individuals). Materials and methods. Patients with end-stage renal disease (3387) and donors (3646) older than 18 years were examined. a molecular genetic method using Protrans assays (Germany) for the examination of blood samples from HLA-A, в-, DRB1-loci was applied. Results. The features of the distribution of HLA-A-, в-, DR-antigens in patients with chronic kidney disease (CKD) are shown. HLA-A*24; B*37, *40, *50, *54; DRB1 *10, *11, *12 ARE ASSOCIATED WITH CKD. PHENOTYPES WITH HLA-A*02, *03, *25; B*07, *35, *46; DRB1 *01, *08, *15 ANTIGENS HAVE A PROTECTIVE EFFECT. Conclusion. a characteristic profile of the distribution of specificities of the HLA system in patients with chronic kidney disease in the Kazakhstan population was revealed.

Толық мәтін

Рұқсат жабық

Авторлар туралы

I. Ramilieva

Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan

Email: ramileva_84@mail.ru
Physician of the Department of Tissue Immunotyping of (HLA)

A. Turganbekova

Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan

Email: dr.aida@mail.ru
Head of the Department of Tissue Immunotyping of (HLA)

Zh. Burkitbaev

Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan

Email: omninpct16@mail.ru
PhD in Medical Science, Director

S. Abdrakhmanova

Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan

Email: a.saniya@mail.ru
PhD in Medical Sciences, Deputy Director

D. Baymukasheva

Republican State Enterprise on the Right of Economic Use "Scientific and Production Center of Transfusiology" of the Ministry of Health of the Republic of Kazakhstan

Physician of the Department of Tissue Immunotyping of (HLA)

E. Zhiburt

FSBI "N.I. Pirogov National Medical and Surgical Center" of the Ministry of Health of the Russian Federation

Doctor of Medical Sciences, Professor, Head of the Department of Transfusi-ology and Blood Transfusion Problems

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