Parameters of oxidative metabolism of erythrocytes in diabetic nephropathy
- Autores: Kurmanov MS1, Klyuev DA1
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Afiliações:
- Edição: Nº 6 (2010)
- Páginas: 52-53
- Seção: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245951
- ID: 245951
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Resumo
Aim. Assessment of oxidative metabolism parameters of erythrocytes in patients with diabetic nephropathy.
Methods. 49 patients with diabetes mellitus type 1 (age 18 - 49 years) and diabetic nephropathy were included into the study; 10 healthy donors served as controls. In erythrocytes products of lipid peroxidation were determined: dien conjugates (DC) and ketodiens (KD), malone diadehyde (MDA). Activity of antioxidant enzymes - catalase and glutationperoxidase - was evaluated.
Results. In early stages of diabetic nephropathy significant elevation of erythrocyte level of DC, KD and MDA is seen. Erythrocyte activity of antioxidant enzymes in patients with diabetic nephropathy decreases.
Conclusion. Development of diabetic nephropathy is associated with decrease of erythrocyte activity of antioxidant enzymes and elevation of erythrocyte concentration of products of lipid peroxidation.
Methods. 49 patients with diabetes mellitus type 1 (age 18 - 49 years) and diabetic nephropathy were included into the study; 10 healthy donors served as controls. In erythrocytes products of lipid peroxidation were determined: dien conjugates (DC) and ketodiens (KD), malone diadehyde (MDA). Activity of antioxidant enzymes - catalase and glutationperoxidase - was evaluated.
Results. In early stages of diabetic nephropathy significant elevation of erythrocyte level of DC, KD and MDA is seen. Erythrocyte activity of antioxidant enzymes in patients with diabetic nephropathy decreases.
Conclusion. Development of diabetic nephropathy is associated with decrease of erythrocyte activity of antioxidant enzymes and elevation of erythrocyte concentration of products of lipid peroxidation.
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Bibliografia
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