Posttransplatation predictors of results of kidney transplantation


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Resumo

Chronic kidney disease and its outcome in the form of end-stage renal disease is a significant medical and social problem. Kidney allotransplantation is the optimal method of renal replacement therapy. Purpose. Evaluation of postransplantation predictors of outcomes after kidney transplantation. Material and Methods. The study included 350 patients who underwent kidney transplantation; mean follow-up period - 79.1 ± 3.4 months, median follow-up period - 68 months. There were 229 men (65.4%). mean age of patients was 37.1 ± 0.6 years (і2-6і); median age - 38 years. The following outcomes after transplantation were assessed: death, renal allograft loss, and development of chronic allograft dysfunction. Statistical analyses were performed using the SPSS software package, version 16. Results. We have revealed significant (Р <0.05) predictors of outcomes after kidney transplantation: the protocol of immunosuppressive therapy on the basis of calcineurin inhibitors, mycophenolate, and corticosteroids, the use of interleukin-2 receptors blockers, monitoring of cyclosporin-A concentrations, delayed graft function, serum creatinine and proteinuria levels after surgery, infectious complications, infection with cytomegalovirus and herpes simplex virus, prophylactic use of antiviral therapy, alanine aminotransferase blood levels, hemoglobin levels, albumin levels, as well as hypertension, labor rehabilitation of the patient, smoking and compliance. Conclusion. Management of identified predictors can improve the prognosis of outcomes after kidney allotransplantation.

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