New approaches to the correction of malnutrition in patients receiving chronic hemodialysis treatment

Purpose. To evaluate the relationship between the level of Helicobacter pylori colonization in the stomach mucous membrane and malnutrition in patients receiving chronic hemodialysis treatment. Material and Methods. The study involved 102 patients with end-stage renal failure treated with chronic hemodialysis, including 52 men and 50 women aged 49 ± 7.7 years. All patients underwent fibrogastroduodenoscopy with a biopsy of the antrum and corpus tissue and the detection of h. pylori (Hp) contamination. Nutritional status and the component structure of the patient’s body were assessed using an integrated method of nutritional assessment, kaliperometry, and bioimpedansometry. Detectio of serum acyl-ghrelin serum levels was performed by the ELISA test using commercial kits (Spi-bio, Montignyle Bretonneux, France). Results. The study has demonstrated the deterioration of a number of basic indicators of nutritional status depending om the presence of h. pylori. The serum acyl-ghrelin levels in patients with Hp colonization in stomach mucous membrane was reduced. After a 14-day Hp eradication therapy, improvement in the basic nutritional indicators and increase in acyl-ghrelin concentrations were detected. Conclusion. h. pylori eradication therapy can be considered as one of the additional methods for the correction of malnutrition in Hp-positive hemodialysis patients.

h. pylori, malnutrition, h. pylori, hemodialysis, acyl-ghrelin, eradication therapy