Effect of VEGF a on the development of tubulointerstitial fibrosis and the probability of achieving complete remission in patients with primary chronic glomerulonephriti


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Objective. evaluation of the effect of vegf a on the development of tubulointerstitial fibrosis (TIF) and the probability of achieving complete remission in patients with primary chronic glomerulonephritis. material and methods. the study included 75 patients aged 18 to 75 years. all participants underwent clinical and laboratory examination, kidney needle biopsy with staining of biopsy samples with a specific labeled antibody to vegf a to determine its expression in kidney tissue. results. the maximum vegf a expression was observed in the initial collecting tubules in all 75 biopsy samples. a direct association was found between the vegf a expression and the severity of tif (r - o.26; p<0.05). logistic regression analysis demonstrated the probability of achieving remission with a minimum vegf a expression equal to 34%, which is by 22% greater than with pronounced expression. Conclusion. Dysregulation of vegf a expression in the kidney tissue leads to the development of tif and a decrease in the probability of reaching the complete remission in patients with primary chronic glomerulonephritis.

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Sobre autores

Aytan Mukhtarova

Rostov State Medical University

Email: ayka.mukhtarova@gmail.com
Head of the Dialysis Department № 2, OOO DC NEPHROS-DON, Cand. Sci. (Med.) degree seeker at the Department of Internal Medicine № 2

Mikhail Batyushin

Rostov State Medical University

Email: batjushin-m@rambler.ru
Dr. Sci. (Med.), Professor, Professor at the Department of Internal Medicine № 2, Head of the Nephrology Department of the Clinic

Elena Sinelnik

Regional Clinical Hospital № 2, Rostov-on-Don

Email: ob2p@mail.ru
Cand.Sci. (Med.), Head of the Department of Morbid Anatomy

Natalya Antipova

Regional Clinical Hospital № 2, Rostov-on-Don

Email: ob2p@mail.ru
Head of the Nephrology Department

Aleksandra Razina

Rostov State Medical University

Email: pasechnik-alexandra@mail.ru
Cand.Sci. (Med.), Nephrologist at the Nephrology Department of the Clinic

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