Mechanisms of albumin loss against the background of the use of modern methods of renal replacement therapy

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The article deals with the issues of renal replacement therapy (RRT) taking into account the latest knowledge in the field of physics and chemistry of polymeric dialysis membranes. Existing and historical information about the classification of membranes for hemodialysis is given. The review also discusses the classification of dialysis membranes, based on the appropriateness of their use for a particular clinical situation, in order to achieve more effective hemodialysis and its modifications, as well as increase the safety of the procedure and reduce episodes of bioincompatibility reactions. The effect of albumin loss during the use of various methods of extracorporeal apparatus detoxification and peritoneal dialysis on the quality of life and survival of patients with end-stage renal disease was evaluated. The mechanisms of protein loss during RRT by adsorption on the hemodialyzer membrane, convective transfer, and elimination into the dialysate are described. In addition, the possibilities of analyzing adsorbed protein fractions under various pathological conditions are presented. The issues of the potentiating effect of hypoalbuminemia as an independent risk factor for adverse outcomes in patients receiving RRT are discussed. Determination of the albumin level and its loss during the procedures for replacing the lost kidney function seems to be a routine method that allows indirect control of basal and energy metabolism, determining the prognosis of treatment with extracorporeal detoxification methods.

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Sobre autores

Aleksandr Litvinov

OOO Baltic Medical Company LLC; Metaco LLP

Autor responsável pela correspondência
Email: dirge@yandex.ru
ORCID ID: 0000-0001-5251-145X

Cand. Sci. (Med.), Leading Researcher; Chief Physician of OOO «Baltic Medical Company»

Rússia, Vladikavkaz; London, UK

Mitkhat Gasanov

Rostov State Medical University

Email: mitkhat@mail.ru
ORCID ID: 0000-0001-5856-0404

Cand. Sci. (Med.), Associate Professor, Rostov State Medical University, Department of Internal Medicine No. 1

Rússia, Rostov-on-Don

Yuliya Kuznetsova

Rostov State Medical University

Email: ul.kuznetsova04@mail.ru
ORCID ID: 0000-0002-5740-3009

Student at the Rostov State Medical University

Rússia, Rostov-on-Don

Said Gergia

OOO DC Nephros-Don

Email: boss.gergiya@mail.ru
ORCID ID: 0009-0004-3799-0674

Nephrologist at OOO DC Nephros-Don

Rússia, Rostov-on-Don

Sergey Shevchenko

Rostov State Medical University

Email: shevchenko19967@mail.ru
ORCID ID: 0000-0002-0151-0761

General Practitioner, Rostov State Medical University

Rússia, Rostov-on-Don

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