Use of tocilizumab in treatment of chronic active antibody mediated kidney transplant rejection

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Resumo

Objective: to evaluate the safety and efficacy of tocilizumab in the treatment of chronic active antibody-mediated kidney transplant rejection.

Material and methods: A prospective study of tocilizumab use in the treatment of morphologically verified chronic active antibody-mediated transplant rejection was conducted in 15 kidney recipients.

Results and conclusion: in recipients who lost their graft function during the observation period, a high chronicity index was found according to morphological examination of the graft. After administration of tocilizumab, a decrease in the level of microvascular inflammation was observed.

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Sobre autores

Nadezhda Rapetskaya

Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology

Autor responsável pela correspondência
Email: n.rapetskaja@gmail.com
ORCID ID: 0009-0005-4560-1162

Nephrologist, Department of Transplant Nephrology

Belarus, Minsk

Kirill Komissarov

Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology; Belarusian State Medical University

Email: kirill_ka@tut.by
ORCID ID: 0000-0002-2648-0642

PhD (Med. Sci), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation

Belarus, Minsk; Minsk

Margarita Dmitrieva

Belarusian State Medical University

Email: mvdmitieva@inbox.ru
ORCID ID: 0000-0002-2958-9424

PhD (Med. Sci), Associate Professor, Department of Pathological Anatomy and Forensic Medicine

Belarus, Minsk

Tatiana Liatkoyskaya

Belarusian State Medical University

Email: taletkovskaya@mail.ru
ORCID ID: 0000-0002-9381-2985

PhD (Med. Sci), Associate Professor, Head of the Department of Pathological Anatomy and Forensic Medicine

Belarus, Minsk

Aleh Kalachyk

Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology

Email: oleg_kalachik@hotmaill.com
ORCID ID: 0009-0002-6954-675X

DSc (Med Sci), Professor, Deputy Director for Medical Affairs

Belarus, Minsk

Bibliografia

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2. Fig. 1. Dynamics of the MVI index in group 2 after treatment with tocilizumab

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3. Fig. 2. Dynamics of laboratory parameters in group 2 after treatment with tocilizumab: a)<зTeatinine, b) GFR, c) proteinuria, d) anti-Hb'I antibodies

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