За пределами контроля гликемии: нефропротективные эффекты агонистов рецепторов глюкагоноподобного пептида 1
- Авторы: Шамхалова М.Ш.1, Скляник И.А.1, Шестакова М.В.1
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Учреждения:
- ФГБУ «НМИЦ эндокринологии» Минздрава РФ
- Выпуск: Том 13, № 3 (2021)
- Страницы: 84-91
- Раздел: Статьи
- URL: https://journals.eco-vector.com/2075-3594/article/view/273861
- DOI: https://doi.org/10.18565/nephrology.2021.3.84-91
- ID: 273861
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Аннотация
Хроническая болезнь почек у пациентов с сахарным диабетом (СД) - лидирующая причина терминальной почечной недостаточности (ТПН), определяющая высокий риск сердечно-сосудистой патологии и смертности. Успехи в лечении СД не отменяют риски ТПН, а сдвигают их в соответствии с возрастом и длительностью заболевания. Современные сахароснижающие препараты - агонисты рецепторов глюкагоноподобного пептида 1 (арГПП-1), эффективно контролирующие гликемию, компоненты метаболического синдрома, значимо снижающие риск первичной 3-компонентной конечной точки (МАСЕ), по данным крупных исследований сердечно-сосудистой безопасности, обладают недооцененным нефропротективным потенциалом. Ренальные эффекты арГПП-1 определены противовоспалительными, антиапоптотическими, антиоксидантными возможностями препаратов этой группы. в статье представлен анализ исследований, посвященных изучению свойств арГПП-1.
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Об авторах
Минара Шамхаловна Шамхалова
ФГБУ «НМИЦ эндокринологии» Минздрава РФ
Email: shamkhalova@mail.ru
д.м.н
Игорь Александрович Скляник
ФГБУ «НМИЦ эндокринологии» Минздрава РФ
Email: sklyanik.igor@gmail.com
научный сотрудник
Марина Владимировна Шестакова
ФГБУ «НМИЦ эндокринологии» Минздрава РФ
Email: nephro@endocrincentr.ru
д.м.н., профессор, академик РАН
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