За пределами контроля гликемии: нефропротективные эффекты агонистов рецепторов глюкагоноподобного пептида 1


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Аннотация

Хроническая болезнь почек у пациентов с сахарным диабетом (СД) - лидирующая причина терминальной почечной недостаточности (ТПН), определяющая высокий риск сердечно-сосудистой патологии и смертности. Успехи в лечении СД не отменяют риски ТПН, а сдвигают их в соответствии с возрастом и длительностью заболевания. Современные сахароснижающие препараты - агонисты рецепторов глюкагоноподобного пептида 1 (арГПП-1), эффективно контролирующие гликемию, компоненты метаболического синдрома, значимо снижающие риск первичной 3-компонентной конечной точки (МАСЕ), по данным крупных исследований сердечно-сосудистой безопасности, обладают недооцененным нефропротективным потенциалом. Ренальные эффекты арГПП-1 определены противовоспалительными, антиапоптотическими, антиоксидантными возможностями препаратов этой группы. в статье представлен анализ исследований, посвященных изучению свойств арГПП-1.

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Об авторах

Минара Шамхаловна Шамхалова

ФГБУ «НМИЦ эндокринологии» Минздрава РФ

Email: shamkhalova@mail.ru
д.м.н

Игорь Александрович Скляник

ФГБУ «НМИЦ эндокринологии» Минздрава РФ

Email: sklyanik.igor@gmail.com
научный сотрудник

Марина Владимировна Шестакова

ФГБУ «НМИЦ эндокринологии» Минздрава РФ

Email: nephro@endocrincentr.ru
д.м.н., профессор, академик РАН

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