Prediction of urolithiasis development in patients on statin therapy taking into account genetic polymorphisms

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Background. With prolonged use of statins, some patients experience the development of side effects. Damage to organs and systems can be caused by both the direct toxic effect of statin therapy and mediated through immunopathological reactions of the body. Researchers around the world are most interested in the association of urolithiasis with different alleles of genes involved in the regulation of vitamin D metabolism.

Description of the clinical case. The article describes a clinical case of determining the genetic polymorphism 283 A> G (BsmI) of the VDR gene in a patient with urolithiasis during statin therapy. The expected results of using the laboratory test – an increase in the efficiency of using immunogenetic predisposition for the early diagnosis of statin-induced urolithiasis.

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作者简介

Alena Kovalenko

Saratov State Medical University named after V.I. Razumovsky

编辑信件的主要联系方式.
Email: alena.kovalenko@mail.ru
ORCID iD: 0000-0003-4535-3793

Senior Lecturer, Department of Biochemistry and Clinical Laboratory Diagnostics

俄罗斯联邦, Saratov

Viktoria Nikitina

Saratov State Medical University named after V.I. Razumovsky

Email: vik-nik72@mail.ru
ORCID iD: 0000-0002-8893-8612

PhD, Associate Professor, Department of Biochemistry and Clinical Laboratory Diagnostics

俄罗斯联邦, Saratov

参考

  1. Аполихин О.И., Сивков А.В., Константинова О.В. и др. Поиск полиморфных вариантов кандидатных генов мочекаменной болезни в российской популяции. Эксперим. и клин. урология. 2013;3:56–60. [Apolikhin O.I., Sivkov A.V., Konstantinova O.V. et al. Search for polymorphic variants of candidate urolithiasis genes in the Russian population. Exp. Clin. Urol. 2013;3:56–60 (In Russ.)].
  2. Appel G.B. Aminoglycoside nephrotoxicity. Am. J. Med. 1990;88(Suppl. 3C): S16–20.
  3. Okuyama H., Langsjoen P.H., Hamazaki T. et al. Statins Stimulate Atherosclerosis and Heart Failure: Pharmacological Mechanisms. Exp. Rev. Clin. Pharmacol. 2015;8(2):189–99.
  4. Wang S., Wang X., Wu J. Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population. Urol. Res. 2012;40(4):277–84.
  5. Lin Y., Mao Q., Zheng X. Vitamin D receptor genetic polymorphisms and the risk of urolithiasis: a meta-analysis. Urol. Internat. 2011;86:249–55.
  6. Seo I.Y., Kang I.H., Chae S.C., et al. Vitamin D receptor gene Alw I, Fok I, Apa I, Taq I Seo polymorphisms in patients with urinary stone. Urol. 2010;759(4):923–9.
  7. Ferreira L., Pereira A., Heilberg I. Vitamin D receptor and calcium-sensing receptor gene polymorphisms in hypercalciuric stone-forming patients. Nephron Clin. Pract. 2010;114(2):135–44.
  8. Moyano M., Gómez de Tejada M., García Lozano R. Alterations in bone mineral metabolism in patients with calcium kidney stone disease and polymorphism of vitamin D receptor. Preliminary results. Nefrologia. 2007;27:694–703.
  9. Seyhan S., Yavascaoglu I., Kilicarslan H. Association of vitamin D receptor gene Taq I polymorphism with recurrent urolithiasis in children. Int. J. Urol. 2007;14:1060–2.
  10. Shakhssalim N., Kazemi B., Basiri A. Association between calcium-sensing receptor gene polymorphisms and recurrent calcium kidney stone disease: a comprehensive gene analysis. Scand. J. Urol. Nephrol. 2010;44:406–11.
  11. Chou Y.H., Woon P.Y., Chen W.C. A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. Publ. Library Sci. One (USA). 2011;6(9):1–9.
  12. Vezzoli G., Scillitani A., Corbetta S. Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism. Eur. J. Endocrin. 2011;164:421–7.
  13. Vezzoli G., Terranegra A., Arcidiacono T. Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region. Nephrol. Dial. Transplant. 2010;25:2245–52.
  14. Вихарева А.А., Сафьяник Е.А., Изможерова Н.В. и др. Оценка влияния полиморфизма гена рецептора витамина D A283G на тяжесть менопаузальных расстройств и качество жизни постменопаузальных женщин города Екатеринбурга. Фармакогенетика и фармакогеномика. 2021;(2):4–5. [Vikhareva A.A., Safyanik E.A., Izmozherova N.V. et al. Evaluation of the effect of vitamin D A283G receptor gene polymorphism on the severity of menopausal disorders and the quality of life of postmenopausal women in Yekaterinburg. Pharmacogenet. Pharmacogenom. 2021;(2):4–5 (In Russ.)].
  15. Коваленко А.В., Никитина В.В., Бородулин В.Б. Анализ полиморфизмов гена VDR с целью прогнозирования предрасположенности развития осложнений мочекаменной болезни у больных на фоне приема статинов. В сборнике: Молекулярная диагностика. Сборник трудов Х Юбилейная международная научно-практическая конференция. М., 2021. С. 387–388. [Kovalenko A.V., Nikitina V.V., Borodulin V.B. Analysis of polymorphisms of the VDR gene in order to predict the predisposition of urolithiasis complications in patients taking statins. In the collection: Molecular diagnostics. Proceedings of the 10th Anniversary International Scientific and Practical Conference. M., 2021. P. 387–388 (In Russ.)].

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