Ginsenosides as Promising Therapeutic Agents for Glioma: Mechanisms of Action and Future Perspectives
- Autores: Moftakhar A.1, Najafi S.2, Khoshnam S.E.3, Farzaneh M.4
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Afiliações:
- Department of Biology, Faculty of Basic Sciences and Engineering, University of Gonbad Kavous
- Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences
- Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences
- Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences
- Edição: Volume 18, Nº 2 (2024)
- Páginas: 53-60
- Seção: Biochemistry
- URL: https://journals.eco-vector.com/2212-7968/article/view/643875
- DOI: https://doi.org/10.2174/0122127968305352240929154003
- ID: 643875
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Resumo
Brain cancers, particularly gliomas, are a significant cause of mortality worldwide. Gliomas are primary tumors of the central nervous system (CNS) and are characterized by diverse clinical and biological features. Despite advancements in clinical approaches and surgical techniques, the treatment of high-grade gliomas still poses multiple challenges. This article focuses on a key active substance found in Panax ginseng called Ginsenosides. Ginsenosides belong to a specific class of triterpenoid saponins and have demonstrated various therapeutic effects, including neuroprotective, anticancer, anti-inflammatory, and neuroprotective functions. These compounds have shown potential in the treatment of gliomas and other cancers. Several pathways associated with ginsenosides, such as Rg3, Rh2, Rd, and Rb1, have been extensively studied, and these compounds have been proposed as potential targets in glioma treatment. The precise mechanisms of action of ginsenosides in gliomas are still being investigated, but their ability to modulate various signalling pathways and exert multiple therapeutic effects makes them promising candidates for further research and development. Clinical trials and additional studies are necessary to validate their therapeutic benefits and determine the optimal dosage, administration route, and potential combination with other treatment modalities. In summary, ginsenosides, the active compounds found in Panax ginseng, exhibit various therapeutic effects, including potential anti-cancer properties in gliomas. Their ability to modulate multiple pathways makes them promising targets for further research in the field of glioma treatment. However, more studies are required to establish their effectiveness and safety in clinical settings.
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Sobre autores
Arya Moftakhar
Department of Biology, Faculty of Basic Sciences and Engineering, University of Gonbad Kavous
Email: info@benthamscience.net
Sajad Najafi
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences
Email: info@benthamscience.net
Seyed Khoshnam
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences
Email: info@benthamscience.net
Maryam Farzaneh
Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences
Autor responsável pela correspondência
Email: info@benthamscience.net
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