BACTERIOPHAGES ARE FACTORS FOR EVOLUTION OF NOSOCOMIAL STRAINS AND MEANS FOR COMBATING INFECTIONS


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Abstract

Healthcare-associated infections (HCAI) are a serious problem throughout the world. The actual task of modern medicine is to study the evolution of HCAI pathogens. Bacteriophages may play a significant role in the formation of pathogenic properties in nosocomial strains. At the same time, bacteriophages are effective agents for the treatment and prevention of HCAI. The mass and irrational use of antibiotics causes HCAI pathogens to acquire multiple resistance, therefore antibiotic effectiveness is reduced or frequently absent. In this connection, bacteriophages as antimicrobial agents assume particular importance. The circulation of phages and their biological properties were studied and nosocomial strains were tested for phage-mediated virulence factors at different hospitals. It was shown that moderate phages might affect the acquisition of virulence factors, as well as antibiotic resistance in bacteria. The therapeutic and preventive efficacies of bacteriophages were evaluated, by using Pseudomonas aeruginosa infection as an example at a traumatology hospital. The application of phages was demonstrated to reduce the incidence of Pseudomonas aeruginosa infection from 40.8 to 8.9%.

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About the authors

L. P ZUYEVA

I.I. Mechnikov Saint Petersburg Medical Academy, Ministry of Health and Social Development of Russia

Email: uzueva@mail.ru

B. I ASLANOV

I.I. Mechnikov Saint Petersburg Medical Academy, Ministry of Health and Social Development of Russia

A. A DOLGIY

I.I. Mechnikov Saint Petersburg Medical Academy, Ministry of Health and Social Development of Russia

A. E GONCHAROV

I.I. Mechnikov Saint Petersburg Medical Academy, Ministry of Health and Social Development of Russia

A. I ARKHANGELSKY

I.I. Mechnikov Saint Petersburg Medical Academy, Ministry of Health and Social Development of Russia

References

  1. Зуева Л.П., Яфаев Р.Х. Эпидемиология: Учебник. — СПб: Фолиант, 2008.
  2. Для сохранения эффективности лекарственной терапии необходимы срочные действия // www.who.int:URL: http://www.who.int/mediacentre/news/releases/2011/whd_20110406/ru/index.html
  3. Brüssow H., Canchaya C., Hardt W.D. Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol. Mol. Biol. Rev. 2004; 68 (3): 560—602.
  4. Petrov V.M., Ratnayaka S., Nolan J.M. et al. Genomes of the T4-related bacteriophages as windows on microbial genome evolution. J. Virol. 2010; 7 (1): 292.
  5. Hendrix R.W., Smith M.C., Burns R.N. et al. Evolutionary relationships among diverse bacteriophages and prophages: all the world’s a phage. Proc. Nat. Acad. Sci. USA. 1999; 96 (5): 2192—2197.

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