MOLECULAR EPIDEMIOLOGICAL CHARACTERISTICS OF HEPATITIS A OUTBREAK IN MOSCOW


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Abstract

The paper presents the results of a molecular biological investigation of a large hepatitis A outbreak recorded in Moscow at the beginning of 2010. The investigation identified HAV subtype IA, which had caused the outbreak of hepatitis A in Moscow, and its genetically closely related strains and subtypes IA and IIIA, unassociated with the outbreak. Phylogenetic analysis of the identified HAV strains allowed one to disclose an epidemic focus of hepatitis A at one of the educational institutions of Moscow, which had not been linked with the major outbreak. The investigation of cases of group hepatitis A diseases has demonstrated that molecular biological methods that make it possible to establish or rule out an epidemiological relationship between different cases of the disease and to detect imported infection cases are of great importance.

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About the authors

I. V KARANDASHOVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: inga.karandashova@pcr.ru

N. N PIMENOV

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

A. D NEVEROV

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

G. V MIKHAILOVSKAYA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

V. A DOLGIN

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare; A.N. Sysin Research Institute of Human Ecology and Environmental Hygiene

S. I BRASLAVSKAYA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

S. V KOMAROVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

I. N LYTKINA

Moscow Department, Federal Inspectorate for the Protection of Consumer Rights and Human Welfare

N. I SHULAKOVA

Moscow Department, Federal Inspectorate for the Protection of Consumer Rights and Human Welfare

G. A SHIPULIN

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

V. P CHULANOV

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

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