TIME COURSE OF CHANGES IN SOME INDICATORS OF ENDOGENOUS INTOXICATION IN ERYSIPELAS

Objective. To estimate the level of low- and medium-molecular-weight (LMW and MMW) substances and oligopeptides (OP) in the plasma, red blood cells, and urine of patients with erysipelas, as well as intoxication indices and coefficients in the dynamics of this disease. Subjects and methods. 112 patients with different forms of erysipelas were examined. The levels of LMW and MMW substances were measured by the method developed by M.Ya. Malakhova and modified by O.L. Grebneva et al. and the concentration of OP was estimated by that of O. N. Lowry in the plasma, red blood cells, and urine of the examinees. Results. There was a relationship of the indices under examination to the period and severity of the disease and the presence of comorbidities. The elevated levels of LMW and MMW substances and OP and redistribution between the body’s biological environments determine a change in the integral intoxication index and depend on the stage and degree of a pathological process. Conclusion. The determination of the indicators studied in erysipelas may serve as a marker of intoxication syndrome. They can be used as additional criteria for evaluating the severity of the process and the completeness of recovery.

endogenous intoxication syndrome, low- and medium-molecular weight substances, oligopeptides, intoxication indices and coefficients, erysipelas