THE IMMUNOLOGICAL AND EPIDEMIOLOGICAL EFFICIENCY OF HEPATITIS B VACCINATION: MULTICENTER STUDY RESULTS
- Authors: SHAGINYAN V.R.1, GURAL A.L1, SERGEEVA T.A1, MAKSIMENOK E.V1, MYSHKO O.V1, SADKOVA A.B1
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Affiliations:
- L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
- Issue: No 4 (2013)
- Pages: 20-26
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/276944
- ID: 276944
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Abstract
Objective. To define the indicators of immune response to hepatitis B (HB) vaccination in different periods after immunization and to evaluate its epidemiological efficiency from the detection rates of HBV infection markers in vaccinated and unvaccinated children from different regions of Ukraine. Subjects and methods. 1586 serum samples obtainedfrom HB vaccinated and unvaccinated children in different regions of Ukraine were examined. Enzyme immunoassay was used to measure HBsAg, anti-НВс, and анти-HBs level. Results. Among the vaccinated children, there were a large number of negative anti-HBs cases (46.7%) with the highest proportion in the 10-14-year-old group (57.9%). There was evidence supporting the comparable immunological efficiency of two- and three-dose vaccination. The HB vaccination initiated in infants above 1 year of age was shown to be more immunological efficient than neonatal immunization. The epidemiological vaccination efficiency coefficient was 71.2%. There were data on equal HBV infection rates in HB vaccinated and unvaccinated children aged 10-14 years (3.7 and 2.0%, respectively). In the vaccinated children, the presence of HBV infection markers was accompanied by the absence of a protective anti-HBs level. Conclusion. The results of the multicenter study conducted in Ukraine suggest that HB vaccination has displayed a good epidemiological efficiency as a whole. They show the needfor further investigations to determine when to initiate vaccination in infants with no risk of perinatal infection and whether booster immunization is expedient in the low HB prevalence regions.
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About the authors
Valeria R. SHAGINYAN
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: shaginianvaleria@mail.ru
Kiev
A. L GURAL
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: algural@rambler.ru
Kiev
T. A SERGEEVA
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: tsergeyev@rambler.ru
Kiev
E. V MAKSIMENOK
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: maksimenok@rambler.ru
Kiev
O. V MYSHKO
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: epidemics@ukr.net
Kiev
A. B SADKOVA
L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases, National Academy of Medical Sciences of Ukraine
Email: epidemics@ukr.net
Kiev
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