CYTOKINE PROFILE IN WOMEN WITH CHRONIC HEPATITIS B IN THE THIRD TRIMESTER OF PREGNANCY
- Authors: KOVALEVA T.A.1, CHUIKOVA K.I1
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Affiliations:
- Siberian State Medical University, Ministry of Health of Russia
- Issue: No 5 (2013)
- Pages: 28-32
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/277065
- ID: 277065
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Abstract
Objective. To study the serum levels of cytokines in women with chronic hepatitis B (CHB) in the third trimester of pregnancy and to assess their relationship to the values of aminotransferases and the level of viral load. Subjects and methods. Thirty pregnant women with CHB at 28-36 weeks’ gestation were examined; a control group consisted of 34 healthy pregnant women. Results. CHB presenting with HBeAg-negative hepatitis without delta infection in the pregnant women was found to be accompanied by the lower serum concentrations of IFN-α, IL-4, and IL-10 in the third trimester. IFN-γ tended to decrease and the content of TNF-α and IL-1β did not significantly differ from those in the healthy women. Conclusion. Correlation analysis revealed that the pregnant women with CHB had positive correlations between the serum concentration of TNF-а and the level of alanine aminotransferase and negative correlations of serum IL-10 content with aminotransferase levels and HBVDNA viral load.
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About the authors
Tatyana A. KOVALEVA
Siberian State Medical University, Ministry of Health of Russia
Email: kta1209@mail.ru
Tomsk
K. I CHUIKOVA
Siberian State Medical University, Ministry of Health of Russia
Email: kirainf@elefot.tsu.ru
Tomsk
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