FEATURES OF ACUTE ENTERIC INFECTIONS IN CHILDREN IN THE ORENBURG REGION

Objective. To determine the clinical and epidemiological features of enteric infections in children in the Orenburg Region in 2008—2012 and the eff icacy of recombinant interferons-a-2 used in the combination therapy for concomitant enteric infections in infants. Subjects and methods. The incidence of acute enteric infections (AEI) in 2008—2012 was analyzed in the children from the Orenburg Region. Fifty children aged 6 months to 3 years with concomitant rotavirus and bacterial infection caused by opportunistic microorganisms were followed up. All the children received recombinant interferon-a-2b (viferon-1). Results. The pattern of AEI underwent changes towards the higher rate of viral diarrheas, mainly that of rotavirus gastroenteritis. There was a correlation of the nosological entities of AEI with the children’s age: the most frequently notified diseases were salmonellosis and shigellosis in preschool and school children, viral diarrheas in 1-3-year-old children, and AEI of mixed etiology in infants during the first two years of life at high-risk for the infection. Conclusion. Incorporation of viferon-1 into combination therapy for mixed rotavirus and bacterial infections promotes the amelioration of clinical syndrome in the acute period of the disease and the stabilization of achieved results.

children, concomitant acute enteric infections, clinical presentation, treatment