Molecular genetic studies in the epidemiology of viral hepatitis: Progress and prospects


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Viral hepatitides are common infectious diseases and remain an important public health problem worldwide. The development of molecular genetic techniques has greatly expanded our understanding of the biology of these infectious pathogens. This article describes the modern concepts of the genetic classification of hepatitis A and B viruses and presents data on the prevalence of their genotypes and subtypes in the world and in Russia. Using these infectious pathogens as an example, the authors unveil the possibilities and prospects for the use of molecular genetic approaches to studying the characteristics of the epidemic process of viral hepatitides.

Full Text

Restricted Access

About the authors

V. P Chulanov

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: vladimir.chulanov@pcr.ru

A. D Neverov

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: neva_2000@mail.ru

I. V Karandashova

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: inga.karadashova@pcr.ru

N. N Pimenov

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: n.pimenov@mail.ru

G. A Shipulin

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: german.shipulin@pcr.ru

References

  1. WНO. Hepatitits A vaccines. WHO position paper. Weekly Epidemiol. Rec. 2000; 75: 38-44.
  2. Jacobsen K.H., Wiersma S.T. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine 2010; 28(41): 6653-6657.
  3. WHO. Factsheet № 204: Hepatitis B. http://www.who.int/mediacentre/factsheets/fs204/en/index.html. Дата просмотра 26.06.2013.
  4. Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V., Siegl G. et al. Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J. Gen. Virology. 1992; 73(Pt 6): 1365-1377.
  5. Nainan O.V., Xia G., Vaughan G., Margolis H.S. Diagnosis of hepatitis a virus infection: a molecular approach. Clin. Microbiol. Rev. 2006; 19(1): 63-79.
  6. Чуланов В.П., Пименов Н.Н., Карандашова И.В., Комарова С.В. Современные особенности эпидемического процесса гепатита А в России и странах Европы, определяющие стратегии его профилактики. Эпидемиол. и инфекц. бол. 2012; 3: 28-34.
  7. Wattanasri N., Ruchusatsawat K., Wattanasri S. Phylogenetic analysis of hepatitis A virus in Thailand. J. Med. Virol. 2005; 75(1): 1-7.
  8. Gharbi-Khelifi H., Ferre V., Sdiri K., Berthome M., Fki L., Harrath R. et al. Hepatitis A in Tunisia: phylogenetic analysis of hepatitis A virus from 2001 to 2004. J. Virol. Meth. 2006; 138(1-2): 109-116.
  9. Costa-Mattioli M., Ferre V., Monpoeho S., Garcia L., Colina R., Billaudel S. et al. Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks. J. Gen. Virol. 2001; 82(Pt 11): 2647-2652.
  10. Munné M.S., Vladimirsky S., Otegui L., Soto S., Brajterman L., Castro R. et al. Molecular characterization of hepatitis A virus isolates from Argentina. J. Med. Virol. 2007; 79(7): 887-894.
  11. De Paula V.S., Niel C., Teves S.C., Villar L.M., Virgolino H., Gaspar A.M. Molecular epidemiology of hepatitis A virus in Brazilian Amazon. J. Gastroenterol. Hepatol. 2006; 21(9): 1435-1438.
  12. Costa-Mattioli M., Domingo E., Cristina J. Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulations. J. Gen. Virol. 2006; 87(Pt 1): 115-118.
  13. Toyoda H., Kumada T., Kiriyama S., Sone Y., Tanikawa M., Hisanaga Y. et al. Clinical and molecular characteristics of hepatitis A virus infections during the years 1992-2003 in Ogaki, a centrally located city of Japan. J. Clin. Virol. 2009; 44(2): 145-148.
  14. Wheeler C., Vogt T.M., Armstrong G.L., Vaughan G., Weltman A., Nainan O.V. et al. An outbreak of hepatitis A associated with green onions. N. Engl. J. Med. 2005; 353(9): 890-897.
  15. Чуланов В.П. Эпидемиологическое и клиническое значение генетической гетерогенности вирусов гепатита А и В. Автореф. дис.. д-ра мед. наук. М., 2013.
  16. Moratorio G., Costa-Mattioli M., Piovani R., Romero H., Musto H., Cristina J. Bayesian coalescent inference of hepatitis A virus populations: evolutionary rates and patterns. J. Gen. Virol. 2007; 88(Pt 11): 3039-3042.
  17. Hanada K., Suzuki Y., Gojobori T. A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes. Mol. Biol. Evol. 2004; 21(6): 1074-1080.
  18. Hutin Y.J., Pool V., Cramer E.H., Nainan O.V., Weth J., Williams I.T. et al. A multistate, foodborne outbreak of hepatitis A. National Hepatitis A Investigation Team. N. Engl. J. Med. 1999; 340(8): 595-602.
  19. Robesyn E., De Schrijver K., Wollants E., Top G., Verbeeck J., Van Ranst M. An outbreak of hepatitis A associated with the consumption of raw beef. J. Clin. Virol. 2009; 44(3): 207-210.
  20. Tallon L.A., Love D.C., Moore Z.S., Sobsey M.D. Recovery and sequence analysis of hepatitis a virus from springwater implicated in an outbreak of acute viral hepatitis. Appl. Environ. Microbiol. 2008; 74(19): 6158-6160.
  21. Yoon Y.K., Chun B.C., Lee H.K., Seo Y.S., Shin J.H., Hong Y.S. et al. Epidemiological and genetic analysis of a sustained community-wide outbreak of hepatitis A in the Republic of Korea, 2008: a hospital-based case-control study. J. Clin. Virol. 2009; 46(2): 184-188.
  22. Robertson B.H., Averhoff F., Cromeans T.L., Han Xh., Khoprasert B., Nainan O.V. et al. Genetic relatedness of hepatitis A virus isolates during a community-wide outbreak. J. Med. Virol. 2000. 62(2)144-150.
  23. Ngui S.L., Granerod J., Jewes L.A., Crowcroft N.S., Teo C.G. Outbreaks of hepatitis A in England and Wales associated with two co-circulating hepatitis A virus strains. J. Med. Virol. 2008. 80(7): 1181-1188.
  24. Sanchez G., Pinto R., Vanaclocha H., Bosch A. Molecular characterization of hepatitis a virus isolates from a transcontinental shellfish-borne outbreak. J. Clin. Microbiol. 2002; 40(11): 4148-4155.
  25. Карандашова И.В., Пименов Н.Н., Неверов А.Д., Михайловская Г.В., Долгин В.А., Браславская С.И. и др. Молекулярно-эпидемиологические особенности вспышки гепатита А в Москве. Эпидемиол. и инфекц. бол. 2012; (3): 9-14.
  26. Courouce A.M., Drouet J., Muller J.Y. Australia antigen subtypes identification. Results. Bibl. Haematol. 1976; (42): 89-127.
  27. Moriya T., Kuramoto I.K., Yoshizawa H., Holland P.V. Distribution of hepatitis B virus genotypes among American blood donors determined with a PreS2 epitope enzyme-linked immunosorbent assay kit. J. Clin. Microbiol. 2002; 40(3): 877-880.
  28. Okamoto H., Tsuda F., Sakugawa H., Sastrosoewignjo R.I., Imai M., Miyakawa Y. et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol. 1988; 69(Pt 10): 2575-2583.
  29. Norder H., Hammas B., Löfdahl S., Couroucé A.M., Magnius L.O. Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. J. Gen. Virol. 1992; 73(Pt 5): 1201-1208.
  30. Kidd-Ljunggren K., Miyakawa Y., Kidd A.H. Genetic variability in hepatitis B viruses. J. Gen. Virol. 2002; 83(Pt 6): 1267-1280.
  31. Tatematsu K., Tanaka Y., Kurbanov F., Sugauchi F., Mano S., Maeshiro T. et al. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J. Virol. 2009; 83(20): 10538-10547.
  32. Huy T.T., Ngoc T.T., Abe K. New complex recombinant genotype of hepatitis B virus identified in Vietnam. J. Virol. 2008; 82(11): 5657-5663.
  33. Norder H., Couroucé A.M., Coursaget P., Echevarria J.M., Lee S.D., Mushahwar I.K. et al. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology 2004; 47(6): 289-309.
  34. Devesa M., Loureiro C.L., Rivas Y., Monsalve F., Cardona N., Duarte M.C. et al. Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia. J. Med.Virol. 2008; 80(1): 20-26.
  35. Arankalle V.A., Murhekar K.M., Gandhe S.S., Murhekar M.V., Ramdasi A.Y., Padbidri V.S. et al. Hepatitis B virus: predominance of genotype D in primitive tribes of the Andaman and Nicobar islands, India (1989-1999). J. Gen. Virol. 2003; 84(Pt 7): 1915-1920.
  36. Stuyver L., De Gendt S., Van Geyt C., Zoulim F., Fried M., Schinazi R.F. et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol. 2000; 81(Pt 1): 67-74.
  37. Suzuki S., Sugauchi F., Orito E., Kato H., Usuda S., Siransy L. et al. Distribution of hepatitis B virus (HBV) genotypes among HBV carriers in the Cote d’Ivoire: complete genome sequence and phylogenetic relatedness of HBV genotype E. J. Med. Virol. 2003; 69(4): 459-465.
  38. Pineiro Y., Mbayed V., Campos R. Evolutionary history of Hepatitis B virus genotype F: an in-depth analysis of Argentine isolates. Virus genes 2003; 27(1): 103-110.
  39. Vieth S., Manegold C., Drosten C., Nippraschk T., Günther S. Sequence and phylogenetic analysis of hepatitis B virus genotype G isolated in Germany. Virus genes 2002; 24(2): 153-156.
  40. Arauz-Ruiz P., Norder H., Robertson B., Magnius L. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J. Gen. Virol. 2002; 83(Pt 8): 2059-2073.
  41. Olinger C.M., Jutavijittum P., Hübschen J.M., Yousukh A., Samountry B., Thammavong T. et al. Possible new hepatitis B virus genotype, southeast Asia. Emerg. Inf. Dis. 2008; 14(11): 1777-1780.
  42. Chu C.J., Keeffe E.B., Han S.H., Perrillo R.P., Min A.D., Soldevila-Pico C. et al. Hepatitis B virus genotypes in the United States: results of a nationwide study. Gastroenterol. 2003; 125(2): 444-451.
  43. Chulanov V., Neverov A., Karandashova I., Dolgin V., Mikhailovskaya G., Lebedeva E. et al. Molecular epidemiology of HBV in Russia. Abstracts Book of 14th International Symposium on Viral Hepatitis and Liver Disease. Shanghai, 2012; 222.
  44. Pontisso P., Petit M.A., Bankowski M.J., Peeples M.E. Human liver plasma membranes contain receptors for the hepatitis B virus pre-S1 region and, via polymerized human serum albumin, for the pre-S2 region. J. Virol. 1989; 63(5): 1981-1988.
  45. Shokrgozar M.A., Shokri F. Subtype specificity of anti-HBs antibodies produced by human B-cell lines isolated from normal individuals vaccinated with recombinant hepatitis B vaccine. Vaccine 2002; 20(17-18): 2215-2220.
  46. Guirgis B.S., Abbas R.O., Azzazy H.M. Hepatitis B virus genotyping: current methods and clinical implications. Int. J. Inf. Dis. 2010; 14(11): е941-е953.
  47. Cowie B. Is there an optimal genetic target for molecular analysis of hepatitis B virus transmission? J. Clin. Microbiol. 2006; 44(8): 3051.
  48. Bracho M.A., Gosalbes M.J., González F., Moya A., González-Candelas F. Molecular epidemiology and evolution in an outbreak of fulminant hepatitis B virus. J. Clin. Microbiol. 2006; 44(4): 1288-1294.
  49. Datta S., Banerjee A., Chandra P.K., Chowdhury A., Chakravarty R. Genotype, phylogenetic analysis, and transmission pattern of occult hepatitis B virus (HBV) infection in families of asymptomatic HBsAg carriers. J. Med. Virol. 2006; 78(1): 53-59.
  50. Desmond C.P., Gaudieri S., James I.R., Pfafferott K., Chopra A., Lau G.K. Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease. J. Virol. 2012; 86(2): 1181-1192.
  51. Maini M.K., Boni C., Lee C.K., Larrubia J.R., Reignat S., Ogg G.S. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 2000; 191(8): 1269-1280.
  52. Zoulim F. Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection. Antiviral. Research. 2004; 64(1): 1-15.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies