The clinical features of acute respiratory viral infections and the improvement of therapy in a group of frequently ill children

Acute respiratory infections are the most common human diseases and one of the main reasons for hospitalizations of children. The investigation was undertaken to study the clinical features of acute respiratory viral infections (ARVI) in frequently ill children (FICs) and to determine the efficiency of preventive treatment with anaferon® for children. During the investigation, the clinical course of ARVI was evaluated in 2 groups of patients aged 3 to 6 years: 1) 20 FICs (a study group) and 2) 20 rarely ill children (a comparison group). Immune parameters were studied over time: on day 1 of inhospital treatment and after a course of preventive treatment with anaferon® for children in FICs for 3 months. The infection index and the epidemiological effectiveness coefficient were calculated. All the FICs were found to have interferon (IFN) system deficiency revealedfrom IFN-у production and a half of the patients had IFN system deficiency from second-to-third-degree IFN-а elaboration, as well as high IgE levels. A three-month cycle of therapy with anaferon® for children in FICs caused positive changes (a two-fold reduction in thefrequency of ARVI episodes, a 1.7-fold decrease in the infection index, and none severe disease forms), confirming the efficiency and safety of the cycle of immune-modifying therapy with anaferon® for children.

acute respiratory viral infections, immune-modifying therapy, frequently ill children