ROLE OF GENETIC DIVERSITY IN THE POPULATION DEMOGRAPHIC EFFECTS OF THE 2009/2013 INFLUENZA PANDEMIC


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Abstract

Among the causes of demographic damage from influenza pandemics, the contribution of genetic characteristics of the population has been insufficiently analyzed. At the same time, the role of the genetic heterogeneity of populations in a multiethnic country and that of the population distribution of HLA types that determine a high susceptibility to influenza and other infectious diseases have engaged attention. Analysis of the 2009/2011 pandemic leads to the conclusion that its demographic effects can be, to a certain extent, attributed to considerable damage to not only clinical risk groups, but also to the genetic clusters of the population with a particular HLA haplotype. Mutations in the type I interferon system genes in antiviral defense also play an undeniable role. This short review article considers the role of the genetic structure of the population in increased genetically determined susceptibility to pandemic influenza for the first time.

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About the authors

Marina N. Dmitrieva

Research Institute of Influenza, Ministry of Health of Russia

Email: office@influenza.spb.ru

L. S KARPOVA

Research Institute of Influenza, Ministry of Health of Russia

Email: epidlab@influenza.spb.ru

O. S KONSHINA

Research Institute of Influenza, Ministry of Health of Russia

Email: olga_ konshina@influenza.spb.ru

L. M TSYBALOVA

Research Institute of Influenza, Ministry of Health of Russia

Email: sovet@influenza.spb.ru

O. I KISELEV

Research Institute of Influenza, Ministry of Health of Russia

V. I POKROVSKY

Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Customer Rights Protection and Human Welfare

Email: crie@pcr.ru

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