CAUSES OF IMMUNOSUPPRESSION IN THE DEVELOPMENT OF NEONATAL SEPSIS


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The literature review analyzes the causes of immunosuppression in neonatal babies with sepsis. It shows the important role of both innate and adaptive immunity factors in the protection of infants against infections in neonatality. The level of expression and polymorphism of Toll-like receptors is noted to be of importance in the development of grampositive and gram-negative neonatal sepsis. The mechanisms of an immune response in neonatal sepsis, which lead to immunosuppression, are considered. Apoptosis of immunocompetent cells is noted to play an important role in the development of sepsis-induced immunosuppression.

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作者简介

Khalit Khaertynov

Kazan State Medical University

Email: khalit65@rambler.ru

V. ANOKHIN

Kazan State Medical University

Email: anokhin56@mail.ru

S. BOICHUK

Kazan State Medical University

Email: boichuksergei@mail.ru

A. RIZVANOV

Kazan (Volga Region) Federal University

Email: rizvanov@gmail.com

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