Papillomavirus-induced gynecological cancers in HIV-infected women


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Abstract

HIV-positive compared to HIV-negative women are more frequently found to have cervical intraepithelial neoplasia and cervical cancer even after adjusting for risk factors, such as age and sexual behavior. Squamous cell dysplasia is also more common in HIV-infected women. High-risk human papillomavirus (HPV) (types 16, 18, 33, 35, 52, and 53) is the major cause of cervical cancer. The HIV-infected women are at risk for chronic HPV infection because of the inability to eliminate HPV. Besides, they have abnormal Pap test results 10 times more often than women in the general population. The absence of clear recommendation for colposcopy and HPV testing in HIV-infected women in Russia and the inadequate gynecological cancer screening coverage of these patients require the elaboration of follow-up algorithms and the introduction of prevention programs.

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About the authors

Anna A. Popova

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare

Email: asya-med@mail.ru

A. G Stepanova

Peoples' Friendship University of Russia

Email: lionne22@mail.ru

A. V Pokrovskaya

Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare

Email: pokrovskaya_av@mail.ru

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