ON THE PROBLEM OF TOXOPLASMOSIS DURING ORGAN TRANSPLANTATION


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Abstract

The problem of toxoplasmosis in organ transplant recipients is associated with that the disease after transplantation in the presence of immunosuppression develops apace and, if no etiotropic therapy is performed, ends fatally. The Russian literature lacks publications on transplantation-related toxoplasmosis.
Objective. ^ analyze investigations of the frequency of invasiveness markers and the severity of toxoplasmosis in solid organ transplant recipients.
Subjects and methods. Sera from 58 patients (46 and 12 recipients after heart and liver transplantation, respectively) were tested in different postoperative periods. Those from 351 blood donors served as a comparison group. The sera were tested for anti-Toxoplasma gondii IgG, IgM, and IgA antibodies.
Results. The investigation indicated the significant importance of higher T. gondii invasiveness in the heart transplant recipients (47.8%) than in the blood donors (31%). Moreover, in all the examined heart and liver transplant recipients, the degree of invasion (IgM, IgA antibodies) was already one order of magnitude higher than that in the donors. The frequency of invasion reactivation markers was also shown to deрend on the duration of the posttransplantation period.
Conclusion. The authors propose to set up a system for the diagnosis, prevention, and treatment of organ transplant recipients, by monitoring toxoplasmosis and comprehensively assessing clinical and laboratory parameters.

About the authors

D B GONCHAROV

Honorary Academician N.F Gamaleya Federal Research Center for Epidemiology and Microbiology,Ministry of Health of Russia

Email: goncharov_toxo@mail.ru <mailto:goncharov_toxo@mail.ru>
Honorary Academician N.F Gamaleya Federal Research Center for Epidemiology and Microbiology,Ministry of Health of Russia

E S IEVLEVA

Honorary Academician N.F Gamaleya Federal Research Center for Epidemiology and Microbiology,Ministry of Health of Russia

Email: photo-interior@mail.ru <mailto:photo-interior@mail.ru>
Honorary Academician N.F Gamaleya Federal Research Center for Epidemiology and Microbiology,Ministry of Health of Russia

T V KRUPENIO

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

Email: ypsa89@mail.ru <mailto:ypsa89@mail.ru>
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

D S PCHELKINA

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

Email: Dianapchelkina@yandex.ru <mailto:Dianapchelkina@yandex.ru>
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

R SH SAITGAREEV

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

Email: rinat.saitgareev@rambler.ru <mailto:rinat.saitgareev@rambler.ru>
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

N I GABRIELYAN

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

Email: labgso@mail.ru <mailto:labgso@mail.ru>
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of Russia

References

  1. Гончаров Д.Б. Значение персистенции Toxoplasma gondii в клинической патологии человека. ЖМЭИ 2006; 4: 92-97.
  2. Speirs G.E., Hakim M., Calne R.Y., Wreghitt T.G. Relative risk of donor-transmitted Toxoplasma gondii infection in heart, liver and kidney transplant recipients. Clin. Transplant. 1988; 2: 257-260.
  3. Orr K.E., Gould F.K., Short G., Dark J.H., Hilton C.J., Corris P.A., Freeman R. Outcome of Toxoplasma gondii mismatches in heart transplant recipients over a period of 8 years. J. Infect. 1994; 29: 249-253.
  4. Mele A., Paterson P.J., Prentice H.G., Leoni P., Kibbler C.C. Toxoplasmosis in bone marrow transplantation: a report of two cases and systematic review of the literature. Bone Marrow Transplantation 2002; 29: 691-698.
  5. Wulf M.W.H., van Crevel R., Portier R., der MeulenC.G., Melchers W.J.G., van der Ven A., Galama J.M.D. Toxoplasmosis after renal transplantation: implications of a missed diagnosis. J. Clin. Microbiol. 2005; 43(7): 3544-3547.
  6. Nasser Q.J., Power R.E., Eng M.P., Hickey D.P., Little D.M. Toxoplasmosis after a simultaneous pancreas and kidney transplantation. Transplant. Proc. 2004; 36(9): 2843-2844.
  7. Fricker-Hidalgo H., Brion J.P., Durand M., ChavanonO., Brenier-Pinchart M.P., Pelloux H. Disseminated toxoplasmosis with pulmonary involvement after heart transplantation. Transpl. Infect. Dis. 2005; 7(1): 38-40.
  8. Gallino A., Maggiorini M., Kiowski W., Martin X., Wunderli W., Schneider J., Turina M., Follath F. Toxoplasmosis in heart transplant recipients. Eur. J. Clin. Microbiol. Infect. Dis. 1996; 15(5): 389-393.
  9. Палтышев И.П., Филатов Н.Н. Основы общей эпидемиологии: специальные методы эпидемиологии (часть 2). М.: ГЕОТАР-Медиа, 2004. 60 с. 10.
  10. Fernàndez-Sabé N., Cervera C., Farinas M.C., Bodro M., Munoz P., Gurgui M., Torre-Cisneros J., Martin-Dávila P., Noblejas A., Len O., García-Reyne A., Del Pozo J.L.,Carratalà J. Risk factors, clinical features, and outcomes of toxoplasmosis in solid-organ transplant recipients: a matched case-control study. Clin. Infect. Dis. 2012; 54(3): 355-361. 11.
  11. Payá E., Noemí I., Tassar R., Catalán P., Avilés C.L. Prophylaxis against Toxoplasma gondii disease in pediatric and adult patients undergoing solid organ and hematopoietic stem cells transplantation. Rev. Chilena Infectol. 2012; 29(Supol. l): 37-39.
  12. Desoubeaux G., Perret-Gallix K., Machet M.C., Sirinelli A., Bailly E., van Langendonck N., Chandenier J. Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context. Ann. Biol. Clin. (Paris) 2012; 70(3): 323-328.
  13. Baliu C., Sanclemente G., Cardona M., Castel M.A., Perez-Villa F., Moreno A., Cervera C. Toxoplasmic encephalitis associated with meningitis in a heart transplant recipient. Transpl. Infect. Dis. 2014; 16(4): 631-633.
  14. Davis C., Manteuffel J. Unusual presentation of Toxoplasma gondii encephalitis. West J. Emerg. Med. 2012; 13(6): 488-490.
  15. Mastrobuoni S., Dell'aquila A.M., Herreros J. Fatal Toxoplasma gondii dissemination in a heart transplant recipient: description of a case. Case Rep. Transplant. 2012; 2012: Article ID 524279.
  16. Strabelli T.M., Siciliano R.F., Vidal Campos S., Bianchi Castelli J., Bacal F., Bocchi E.A., Uip D.E. Toxoplasma gondii myocarditis after adult heart transplantation: successful prophylaxis with pyrimethamine. J. Trop. Med. 2012; 2012: Article ID 853562.
  17. Avkan O.V., Koçak N., Köse H., Unek T., Ozbilgin M., Karademir S., Kaynak S. Ocular toxoplasmosis dev eloped after liver transplantation. Mikrobiyol. Bul. 2012; 46(4): 702-706. 18.
  18. van Hellemond J.J., van Domburg R.T., Caliskan K., Birim O., Balk A.H. Toxoplasma gondii serostatus is not associated with impaired long-term survival after heart transplantation. Transplantation 2013; 96(12): 1052-1058.
  19. Doesch A.O., Ammon K., Konstandin M., Celik S., Kristen A., Frankenstein L., Müller S., Sack F.U., Katus H.A., Dengler T.J. Negative pretransplant se rostatus for Toxoplasma gondii is associated with impaired survival after heart transplantation. Transpl. Int. 2010; 23(4): 382-389.
  20. Scerra S., Coignard-Biehler H., Lanternier F., Suarez F., Charlier-Woerther C., Bougnoux M.E., Gilquin J., Lecuit M., Hermine O., Lortholary O. Disseminated toxoplasmosis in non-allografted patients with hematologic malignancies: report of two cases and literature review. Eur. J. Clin. Microbiol. Infect. Dis. 2013; 32(10): 1259-1268.

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