Genetic markers for HIV infection progression and secondary diseases development


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Abstract

A number of factors, including human genome variability that determines the specific features of an immune response to virus entry and development in the body, influence a risk for and progression rate of HIV infection. The paper reviews studies of the genetic polymorphisms affecting the risk and progression rate of HIV infection, as well as their role in the development of opportunistic infections, including tuberculosis (TB). The studies of the role of genetic markers in patients with HIV/TB coinfection have provided evidence that a number of genetic polymorphisms affect the risk of developing active TB in patients with HIV without regard to other risk factors. However, the results obtained at this moment cannot be used in clinical practice to improve the diagnosis and prevention of TB in HIV-infected patients, because these require specification and further investigations on large patient samples and among representatives of different ethnic groups.

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About the authors

E. I Kulabukhova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare

Email: ekulabukhova@mail.ru
Moscow

A. V Kravchenko

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare

Email: kravtchenko@hivrussia.net
Moscow

V. N Zimina

Peoples' Friendship University of Russia

Email: vera-zim@yandex.ru
Moscow

A. V Pokrovskaya

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare

Email: pokrovskaya_av@mail.ru
Moscow

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