Acute enteric infections in adults: Assessment of intestinal microflora and the efficacy of aminodihydrophthalasindione sodium as part in their combination therapy

Objective. To evaluate the opportunistic intestinal microflora (OIM) in acute enteric infections (AEI) in adults and the efficacy of aminodihydrophthalasindione sodium (ADPNa) as part of their combination therapy. Materials and methods. Rectal swabs were used to determine OIM in the dynamics of the disease in 2 patient groups. Each group included 30 patients of both sexes, aged 18 to 60 years, with a disease duration of no more than 48 hours at admission and a temperature less than 38.5 °C and without signs of hemorrhagic colitis. Group 1 received conventional therapy; Group 2 additionally used ADPNa. The qualitative and quantitative composition of OIM and its susceptibility to various antibacterial drugs was estimated. Results. The representatives of only OIM, that was susceptible to the main classes of antibiotics in 68-90% of cases, were isolated in all the patients with AEI. ADPNa used in addition to the standard treatment regimen assisted in reducing the duration of clinical manifestations of the disease and in recovering the normal amount of OIM and reduced antimicrobial resistance to penicillins and first-, second-, and third-generation cephalosporins. Conclusion. The results of the study can recommend ADPNa to be incorporated into the combination therapy of AEI. It is also advisable to administer ADPNa during antibiotic therapy with penicillins or cephalosporins.

acute enteric infections, opportunistic flora, aminodihydrophthalasindione sodium, antimicrobial resistance