Investigation of the efficacy and inhalation toxicity of an air disinfectant in the human breathing zone for the nonspecific prevention of airborne infections

Anton Yu. Scopin; Скопин Антон Юрьевич; Lyudmila S. Fedorova; Федорова Людмила Самуиловна; Dmitry L. Vinogradov; Виноградов Дмитрий Леонидович; Elena V. Karaduleva; Карадулева Елена Валерьевна; Ruslan G. Goncharov; Гончаров Руслан Георгиевич; Angelina V. Kochkina; Кочкина Ангелина Владимировна; Alina E. Gordeeva; Гордеева Алина Евгеньевна; Vyacheslav A. Evdokimov; Евдокимов Вячеслав Александрович; Roman V. Razzhivin; Разживин Роман Вячеславович; Vladimir I. Novoselov; Новоселов Владимир Иванович

Investigation of the efficacy and inhalation toxicity of an air disinfectant in the human breathing zone for the nonspecific prevention of airborne infections

Authors: Scopin A.Y.¹^,2, Fedorova L.S.¹^,2, Vinogradov D.L.², Karaduleva E.V.³, Goncharov R.G.³, Kochkina A.V.³, Gordeeva A.E.³, Evdokimov V.A.³, Razzhivin R.V.³, Novoselov V.I.³
Affiliations:
1. Research Institute of Disinfectology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
2. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
3. Institute of Cell Biophysics
Issue: No 4 (2017)
Pages: 71-77
Section: Articles
URL: https://journals.eco-vector.com/2226-6976/article/view/278650
ID: 278650

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription or Fee Access

Abstract
Full Text
About the authors
References
Supplementary files
Statistics

Abstract

Objective - to determine the efficacy and inhalation toxicity of the chlorine dioxide (CD) generator Barrier Reef used as a personal air disinfectant to inactivate the pathogens of airborne infections. The investigations conducted at the Research Institute of Influenza, Ministry of Health of Russia (Saint Petersburg), showed that the CD generator had high virucidal activity against influenza virus; when CD was used at low, low-toxic concentrations, the virus titer in the air samples was reduced by 90% at 1-3 min, by 97% at 3-5 min, and by 99% at 10-12 min. The agent was effective at least 30 days. The inhalation toxicity of CD was investigated in the experiments using the rats that were kept in an atmosphere of CD for a certain time. Then the structure of the trachea and lungs was histologically determined; the degree of oxidative stress was estimated from the tissue level of malonic aldehyde and the changes in the gene expression of all classes of antioxidant enzymes (a total of 15 different enzymes). The structure of the tracheal and lung epithelium was ascertained to be completely preserved; in this case, there were no increases in apoptotic cell death in both tissues or in lipid peroxidation in lung tissue. The enhanced protection of tracheal and lung epithelial cells against the highly toxic reactive oxygen species generated in the tissues is associated with the activation of gene expression of antioxidant enzymes in the epithelium, which is observed within the f irst hours after action of CD. The results of the investigations allow the air disinfectant Barrier Reef to be recommended for the prevention of airborne infections.

Keywords

chlorine dioxide, airborne infections, upper airway, prevention

Full Text

References

Карпова Л.С., Пелих М.Ю., Еропкин М.Ю., Поповцева Н.М., Столярова Т.П., Столяров К.А., Соминина А.А., Киселев О.И. Эпидемиологическая ситуация по гриппу в мире и России в сезон 2014-2015 годов. Эпидемиология и вакцинопрофилактика 2015; (4): 8-17.
Бурцева Е.И., Федякина И.Т., Кириллова Е.С., Трушакова С.В., Феодоритова Е.Л., Беляев А. Л., Краснослободцев К. Г., Мукашева Е.А., Гарин Е.О., Оскерко Т.А., Аристова B.А., Львов Д.К. Заболеваемость гриппом в январе-марте 2016 г. в РФ. Эпидемический и пандемический потенциал вируса гриппа A(Н1N1)PDM09. Пульмонология 2016; (4): 436-43.
Зарубаев В.В., Штро А.А., Светницкий Е.Н. Изучение эффективности обеззараживателя воздуха нового типа - генератора диоксида хлора на примере вируса гриппа A (H1N1)pdm09 в составе аэрозоля. Лечащий врач 2016; (11): 1-3. https://medi.ru/info/12755/
Kuroyama I., Osato S., Nakajima S., Kumota R., Ogawa T. Environmental monitoring and bactericidal efficacy of chlorine dioxide gas in a dental office. Biocontrol. Sci. 2010; 15: 103-9.
Rastogi V.K., Ryan S.P., Wallace L., Smith L.S., Shah S.S., Martin G.B. Systematic valuation of the efficacy of chlorine dioxide in decontamination of building interior surfaces contaminated with anthrax spores. Appl. Environ Microbiol. 2010; (76): 3345-51.
Cиpота Т.В., Cафpонова В.Г., Амелина А.Г., Мальцева В.Н., Авхачева Н.В., Софин А.Д., Янин В.А., Мубаpакшина Э.К., Pоманова Л.К., Новоcелов В.И. Действие отpицательныx ионов воздуха на оpганы дыхания и кровь. Биофизика 2008; (53): 886-93.
Новоселов В.И. Роль пероксиредоксинов при окислительном стрессе в органах дыхания. Пульмонология 2012; (10): 80-8.
Новоселов В.И., Мубаракшина Э.К., Янин В.А., Амелина C.Е., Фесенко Е.Е. Роль ангиоксидантпых систем в регенерации эпителия трахеи после термического ожога верхних дыхательных путей. Пульмонология 2008; (6): 80-3.
Paulet G., Desbrousses S. On the toxicology of chlorine dioxide. Arch. Mal. Prof. 1972; (33): 59-61.
Paulet G., Desbrousses S. Actions of discontinuous exposure to chlorine dioxide (ClO2) on the rat. Arch. Mal. Prof. 1974; (35): 797-804.
Chuchalin A.G., Novoselov V.I., Shifrina O.N., Soodaeva S.K., Yanin V.A., Barishnikova L.M. Peroxiredoxin VI in human respiratory system. Respir. Med. 2003; (97): 147-51.

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

Investigation of the efficacy and inhalation toxicity of an air disinfectant in the human breathing zone for the nonspecific prevention of airborne infections

Full Text

Abstract

Keywords

Full Text

About the authors

References

Supplementary files

This website uses cookies