Antibiotic susceptibility of Streptococcus pneumoniae, causing meningitis in Moscow

Objective. Determination of antibiotic susceptibility of Streptococcus pneumoniae isolated from patients with pneumococcal meningitis in Moscow. Materials and methods. For the period 2006-2017, 99 strains were studied. The susceptibility of Streptococcus pneumoniae to a number of antibacterial drugs was established by the E-tests and diffusion test. Results. The level of resistance to benzylpenicillin was 5.1%, to erythromycin - 11.1%. The proportion of multiresistant strains was determined at the level of 6.1%. An increase in the susceptibility potential of pneumococcus to benzypenicillin, trimethoprim-sulfamethoxazole, levofloxacin, ceftriaxone was noted. On the contrary, an increase in the strains potential of resistance to macrolides and tetracycline was revealed. In relation to the serotype landscape of resistant strains, serotypes included in the 13-valent conjugated pneumococcal vaccine: 6B, 19F, 3, 23F, 18C and 19F, 14, 6A, 23F, 7F, respectively, prevailed both in the pre-vaccination and the post-vaccination period. Conclusion. Considering the increasing incidence of pneumococcal meningitis, high mortality rates, as well as the development of antibacterial resistance mechanisms in pneumococcal strains, there is a growing need to increase vaccination coverage of children to the targeted indicator and expand immunization programs against pneumococcal infection.

pneumococcal infection, pneumococcus, meningitis, antibiotic resistance