ECONOMIC DAMAGE CAUSED BY THE DISEASES HERPES ZOSTER AND POSTHERPETIC NEURALGIA


Cite item

Full Text

Abstract

Herpes zoster (HZ) is a human viral infectious disease characterized by a skin and nervous system lesion that has a common etiology and a close pathogenetic relationship to varicella. The topicality of HZ is due to its relatively widespread, the chance of long-term and severe complications as postherpetic neuralgia (PHN) in a large portion of patients, a severe clinical course, and frequent recurrences in risk-group patients (those infected with HIV, those with cancer and other diseases). The purpose of the study was to estimate the economic damage caused by HZ and PHN. The direct medical costs of out- and inpatient treatments in a patient with HZ and PHN were 66 625 and 121 356.2 rubles for uncomplicated (without PHN) and complicated (with PHN) HZ, respectively. In the Russian Federation, the annual total direct cost of drug provision and medical care for HZ and PHN was approximately 6 940 598 thousand rubles. The total loss due to HZ and PHN as direct and indirect costs in the Russian Federation was multicomponent and multifactorial and it amounts to 10 619 251.7 thousand rubles a year.

Full Text

Restricted Access

About the authors

I. L SHAKHANINA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow

Email: Irina_Mikheeva@mail.ru

E. V VORONIN

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow

I. V MIKHEYEVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow; I.M. Sechenov First Moscow State Medical University

I. N LYTKINA

I.M. Sechenov First Moscow State Medical University

N. N FILATOV

I.M. Sechenov First Moscow State Medical University

References

  1. Покровский В.И., Пак С.Г., Брико Н.И., Данилкин Б.К. Инфекционные болезни и эпидемиология. М.: ГЭОТАР-Медиа; 2007.
  2. Breuer J., Whitley R. Varicella zoster virus: natural history and current therapies of varicella and herpes zoster. Herpes 2007; 14 (suppl .2): 25-29.
  3. Atkinson W., Hamborsky J., McIntyre L. et al. Epidemiology and prevention of vaccine-preventable diseases. 10th ed. Washington DC: Public Health Foundation; 2007: 175-196.
  4. Portenoy R.K., Duma C., Foley K.M. Acute herpetic and postherpetic neuralgia: clinical review аnd current management. Ann Neurol. 1986; 20(6): 651-664.
  5. Thomas S.L., Hall A.J. What does epidemiology tell us about risk factors for herpes zoster? Lancet Infect. Dis. 2004; 4: 26-33.
  6. Edmunds W. J., Brisson M., Rose J. D. The epidemiology of herpes zoster and potential cost-effectiveness of vaccination in England and Wales. Vaccine 2001; 19 (23-24); 3076-3090.
  7. Loeser J.D. Herpes zoster and postherpetic neuralgia. Pain 1986; 25(2): 149-164.
  8. Attal N., Gruccu G. at al. EFNS guidelines on pharmacological treatment of neuropathic pain. Eur. J. Neurol. 2006; 13: 1153-1169.
  9. Scott F.T., Johnson R.W., Leedham-Green M. et al. The burden of herpes zoster: a prospective population based study. Vaccine 2006; 24: 1308-1314.
  10. http://www.poisklekarstv.ru
  11. Dworkin R.H., Portenoy R.K. Pain and its persistence in herpes zoster. Pain 1996; 67: 241-251.
  12. Волкова Л.И. Современные аспекты лечения и профилактики постгерпетической невралгии. Фармацевтич. вестн. 2006; 16(421).
  13. Денисов И.Н., Власов В.В., Дедеу Т. и др. Опоясывающий лишай и постгерпетическая невралгия. В кн.: Краткий протокол ведения пациентов в практике семейного врача. http: www.dermatolog4you.ru/stat/klin_rec/gerpes_ zoster.html.
  14. Постановление Правительства Москвы от 29.04.2008 № 334-ПП «О территориальной программе государственных гарантий оказания населению города Москвы бесплатной медицинской помощи на 2008 год». М.; 2008.
  15. Insinga R.P., Itzler R.F., Pellissier J.M. et al. The incidence of herpes zoster in a United States administrative database. J. Gen. Intern. Med. 2005; 20: 748-753.
  16. Jumaan A.O., Yu O., Jackson L.A. et al. Incidence of herpes zoster, before and after varicella-vaccination-associated decreases in the incidence of varicella, 1992-2002. J. Infect. Dis. 2005; 191: 2002-2007.
  17. Кимберлин Д.У., Уитли Р.Д. Профилактика опоясывающего лишая с помощью вакцины. Рус. мед. журн. 2008; 16 (9).
  18. Deguen S, Nguyen Phong Chau, Flahaut A. Epidemiology of chickenpox in France (1991-1995). J. Epidemiol. Commun. Hlth. 1998; 52(suppl.1): 46S-49S.
  19. Fleming D.M. Weekly returns service of the royal college of general practitioners. Commun. Dis. Publ. Hlth. 1999; 2: 96-100.
  20. Федеральное руководство по использованию лекарственных средств (формулярная система). Вып. V. М.: ЭХО; 2004.
  21. CD-ROM databases of EBM Guidelines. The Finnish Medical Society. Duodecim Medical Publications Ltd. 2002; 3.
  22. Longmore M., Wilkinson I., Torok E. Oxford handbook of clinical medicine. 5th ed. Oxford: Oxford University Press; 2002.
  23. Wood M.J., Kay R., Dworkin R.H. et al. Oral acyclovir therapy accelerates pain resolution in patients with herpes zoster: a meta-analysis of placebo-controlled trials. Clin. Infect. Dis. 1996; 22: 341-347.
  24. http: www.gks.ru/free_doc/new_site/vvp/dusha98-08.xls. Дата последнего размещения данных - 03.03.2010г.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2011 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies