Determination of the level of an immune stratum in the population of the Republic of Guinea to leptospirosis pathogens

E. V Naydenova; Найденова Е. В; M. Yu Kartashov; Карташов М. Ю; A. V Boyko; Бойко А. В; V. A Safronov; Сафронов В. А; A. A Lopatin; Лопатин А. А; I. V Kutyrev; Кутырев И. В; I. Bacar; Bacar I.; S. Boumbaly; Boumbaly S.; E. V Kolomoets; Коломоец Е. В; S. Kalivogui; Kalivogui S.; M. Y Boiro; Boiro M. Y; S. A Scherbakova; Щербакова С. А

doi:10.18565/epidem.2019.9.2.39-43

Determination of the level of an immune stratum in the population of the Republic of Guinea to leptospirosis pathogens

Authors: Naydenova E.V¹, Kartashov M.Y.², Boyko A.V¹, Safronov V.A¹, Lopatin A.A³, Kutyrev I.V¹, Bacar I.⁴, Boumbaly S.⁴, Kolomoets E.V⁵, Kalivogui S.⁴, Boiro M.Y⁴, Scherbakova S.A¹
Affiliations:
1. Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
2. State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
3. Anti-Plague Center, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
4. Research Institute of Applied Biology of Guinea
5. United Company «RUSAL» (Russian Aluminum)
Issue: Vol 9, No 2 (2019)
Pages: 39-43
Section: Articles
URL: https://journals.eco-vector.com/2226-6976/article/view/287318
DOI: https://doi.org/10.18565/epidem.2019.9.2.39-43
ID: 287318

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Abstract

Objective. To determine the level of an immune stratum of the population in the Republic of Guinea to leptospirosis pathogens. Subjects and methods. In the period May 2015 to March 2018, a total of 1839 serum samples were collected from people living in 4 landscape-geographical zones of Guinea: in the Lower (n = 693 samples), Medium (n = 461), Upper (n = 349), and Forest Guinea (n = 336). The investigation enrolled 904 (49.2%) women and 935(50.8%) men, whose age was 0 to 90 years. The sera were studied at a working dilution of 1:100. Specific IgG antibodies in the sera were detected by enzyme immunoassay (EIA). Results. Antibodies to Leptospira were detected in 90 (4.9%) samples, including 43 (47.7%) that were obtained from women and 47 (52.3%) from men in different age groups. Positive samples were recorded in all landscape-geographical areas of the country. Conclusion. In the Republic of Guinea, the first IgG antibodies to Leptospira were identified in human sera and the level of an immune stratum of the population was determined. There is a need for further study of the spread of leptospirosis pathogens throughout the country; for epizootological monitoring to identify animal species carrying Leptospira, for investigation of the level of the stratum immune to the pathogen in cattle and small ruminants, and for monitoring open water bodies as possible sources of human infection. The findings will be able to determine the natural nidality of leptospirosis and to implement timely preventive (anti-epidemic) measures.

Keywords

leptospirosis, Republic of Guinea, IgG antibodies, immune stratum

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References

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Determination of the level of an immune stratum in the population of the Republic of Guinea to leptospirosis pathogens

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Abstract

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Full Text

About the authors

References

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