Genetic characterization of HIV-1 variants circulating in the Republic of Guinea in 2015-2017


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Abstract

Despite the widespread prevalence of HIV infection in Africa, the specific features of its epidemic in a number of countries in this continent have not been sufficiently studied. Objective. To carry out a molecular biological analysis of HIV variants circulating in the territory of the Republic of Guinea in 2015-2017. Materials and methods. Plasma samples were collected from 5,566 citizens residing in the Republic of Guinea and were tested for HIV infection. The nucleotide sequences of the pol gene of HIV-1 were studied in HIV-positive samples; the structure and level of drug resistance in the virus were determ ined. Results. HIV-1 infection was detected in 200 (3.59%) individuals. No cases of HIV-2 infection were found. The sequences were obtained for 35 samples, 30 (85.71%) of them were AG recombinants, 6 (17.14%) contained nucleoside reverse transcriptase inhibitor (NRTI) and non-NRTIresistance mutations.

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About the authors

I. A Lapovok

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: i_lapovok@mail.ru
Cand. Biol. Sci., Researcher Moscow, Russia

D. V Saleeva

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: dasha_saleeva@inbox.ru
Laboratory Assistant-Researcher Moscow, Russia

A. A Kirichenko

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: kotova-kirichenko@mail.ru
Junior Researcher Moscow, Russia

A. V Murzakova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: murzakova_a.v@mail.ru
Junior Researcher Moscow, Russia

A. E Lopatukhin

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: a.lopatukhin@gmail.com
Researcher Moscow, Russia

D. E Kireev

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: dmitkireev@yandex.ru
Cand. Biol. Sci., Researcher Moscow, Russia

Zh. A Kasyan

Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: kas.ja2na@rambler.ru
Cand. Biol. Sci., Senior Researcher, Departament for Diagnostics of Infectious Disseases Saratov, Russia

D. A Agafonov

Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: stone_dragon@mail.ru
Cand. Biol. Sci., Senior Researcher, Department of Microbiology Saratov, Russia

K. A Nikiforov

Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: nikiforov6666666@mail.ru
Cand. Med. Sci, Senior Researcher, Department of Microbiology Saratov, Russia

N. A Plekhanov

Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: muscari.sp@yandex.ru
Cand. Biol. Sci., Senior Researcher, Department of Microbiology Saratov, Russia

R. B Bayandin

State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: romb@ngs.ru
Cand. Biol. Sci., Researcher Koltsovo, Novosibirsk Region, Russia

M. Yu Kartashov

State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mikkartash@yandex.ru
Cand. Biol. Sci., Senior Researcher Koltsovo, Novosibirsk Region, Russia

A. V Shipovalov

State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: shipovalov_av@vector.nsc.ru
Researche Koltsovo, Novosibirsk Region, Russia

M. P Gashnikova

State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: gashnikova_ mp@vector.nsc.ru
Laboratory Assistant-Researcher Koltsovo, Novosibirsk Region, Russia

G. A Shipulin

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: shipgerman@gmail.com
Cand. Med. Sci., Head, Departament ofMolecular Diagnosti and Epidemiology Moscow, Russia

S. Boumbaly

Research Institute of Applied Biology of Guinea

Email: drboumbaly@yahoo.fr
Cand. Biol. Sci., Director, Medical School Kindia, Republic of Guinea

M. Y Boiro

Research Institute of Applied Biology of Guinea

Email: myboiro@yahoo.fr
Cand. Biol. Sci., Professor, Director-General Kindia, Republic of Guinea

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