Evaluation of the sensitivity of the intestinal microbiota to bacteriophage preparations in infants with dysbiosis

The high incidence of multidrug-resistant strains among the opportunistic enterobacteria isolated from the intestine of infants with dysbioses determines the use of bacteriophages for antibacterial therapy. Objective. To characterize the qualitative and quantitative composition of the large intestinal microflora in infants and to study the sensitivity of the opportunistic pathogens isolated from them to Russian bacteriophage preparations. Subjects and methods. The large intestinal microflora was studied in 870 infants at risk for acute intestinal infections. The sensitivity of650 opportunistic enterobacterial isolates from infants to bacteriophages was examined by the sterile spot method. Results. All the infants were found to have microbiocenotic disorders, grades 2 and 3 being found in 80.5% of cases. There was a low content of bifidobacteria and a large percentage of opportunistic pathogens in associations. Of the 650 opportunistic enterobacterial strains, the high and low sensitivities to bacteriophages were noted in 53.0 ± 2.0 and 10.0 ± 1.1% of the cultures, respectively; resistance to bacteriophages was seen in 37.0 ± 1.8%. Conclusion. Opportunistic microorganisms isolated from infants are characterized by varying degrees of sensitivity to bacteriophage preparations made in Russia.

opportunistic microorganisms, bacteriophages, infants, intestinal microbiocenosis, dysbiosis