Schizophrenia and toxoplasmosis: analysis of their association


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Toxoplasmosis is a common parasitic disease in humans and animals, which is caused by the protozoan Toxoplasma gondii. About one-third of the world’s population is infected with Toxoplasma. It used to be that toxoplasmosis was asymptomatic in healthy people. However, there is more and more evidence that latent toxoplasmosis alters human behavior and affects the development of neuropsychiatric and neurodegenerative diseases, including schizophrenia. The paper considers the facts proving the impact of Toxoplasma invasion on the development of schizophrenia: there is a higher rate of Toxoplasma infection in schizophrenic patients than in the local population; the appearance of clinical schizophrenia symptoms in T. gondii-infected patients; an antiprotozoal effect of some antipsychotic drugs; an association of latent toxoplasmosis with treatment-resistant schizophrenia. It also discusses possible mechanisms by which T. gondii may affect the development of schizophrenia when applied to the classical hypotheses of this disease and the prospects for studying the association.

全文:

受限制的访问

作者简介

Vasilisa Kovaleva

M.V. Lomonosov Moscow State University; Honorary Academician N.F. Gamaleya National Research Center for Epidemiology and Microbiology

Email: vasilisa.kovaliova@gmail.com
Laboratory Researcher, Honorary Academician Moscow, Russia

Dmitriy Goncharov

Honorary Academician N.F. Gamaleya National Research Center for Epidemiology and Microbiology Ministry of Health of Russia

Email: goncharov_toxo@mail.ru
Cand. Biol. Sci., Head of Laboratory of protozoan infections Moscow, Russia

Andrey Zhuravlev

M.V. Lomonosov Moscow State University

Email: ayzhur@mail.ru
BD, Professor, Biological Faculty Moscow, Russia

Evgeniya Abbazova

Honorary Academician N.F. Gamaleya National Research Center for Epidemiology and Microbiology Ministry of Health of Russia

Email: janifer@inbox.ru
Cand. Med. Sci., Researcher, Honorary Academician Moscow, Russia

Irina Titova

Honorary Academician N.F. Gamaleya National Research Center for Epidemiology and Microbiology Ministry of Health of Russia

Email: i-titova-54@yandex.ru
Cand. Med. Sci., Senior Researcher, Honorary Academician Moscow, Russia

参考

  1. Martin E.A. (ed.) Concise medical dictionary. Oxford Quick Reference, 2015.
  2. Karagianis J., Novick D., Pecenak J., Haro J.M., Dossenbach M., Treuer T., Montgomery W., Walton R., Lowry A.J. Worldwide-Schizophre nia Outpatient Health Outcomes (W-SOHO): Baseline characteristics of panregional observational data from more than 17,000 patients. Int. J. Clin. Pract. 2009; 63(11): 1578-88. doi: 10.1111/j.1742-1241.2009. 02191.x
  3. Любов Е.Б., Любов Е.Б., Ястребов В.С., Шевченко Л.С., Чапурин С.А., Чурилин Ю.Ю., Былим И.А., Гажа А.К., Доронин В.В., Косов А.М., Петухов Ю.Л., Фадеев П.Н. Экономическое бремя шизофрении в России. Социальная и клиническая психиатрия 2012; 22(3): 36-42.
  4. Patel K.R., Cherian J., Gohil K., Atkinson D. Schizophrenia: overview and treatment options. Pharmacy and Therapeutics 2014; 39(9): 638-48.
  5. McGrath J., Saha S., Chant D., Welham J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol. Rev. 2008; 30(1): 67-76. doi: 10.1093/epirev/mxn001
  6. Bhugra D. The global prevalence of schizophrenia. PLoS medicine 2005; 2(5). doi: 10.1371/journal.pmed.0020151
  7. McGrath J., Saha S., Welham J., El Saadi O., MacCauley C., Chant D. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC medicine 2004; 2(1): 13. doi: 10.1186/1741-7015-2-13
  8. Yang A.C., Tsai S.J. New targets for schizophrenia treatment beyond the dopamine hypothesis. Int. J. Mol. Sci. 2017; 18(8): 1689. DOI: 10.3390/ ijms18081689
  9. Vlatkovic S., Sagud M., Svob Strac D., Sviben M., Zivkovic M., Vilibic M., Vuksan-Cusa B., Mihaljevic-Peles A., Pivac N. Increased prevalence of Toxoplasma gondii seropositivity in patients with treatment-resistant schizophrenia. Schizophr. Res. 2018; 193: 480. doi: 10.1016/j.schres.2017. 08.006
  10. Gutiérrez-Fernândez J., de Dios Luna del Castillo J., Mananes-Gonzâlez S., Carrillo-Âvila J.A., Gutiérrez B., Cervilla J. A., Sorlôzano-Puerto A. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study. Neuropsychiatric Disease and Treatment 2015; 11: 843. doi: 10.2147/NDT.S79285
  11. Torrey E.F., Bartko J.J., Lun Z.R., Yolken R.H. Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis. Schizophrenia Bulletin 2007; 33(3): 729-36. doi: 10.1093/schbul/ sbl050
  12. Mortensen P.B., Nørgaard-Pedersen B., Waltoft B.L., Sørensen T.L., Hougaard D., Torrey E.F., Yolken R.H. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol. Psychiatry 2007; 61(5): 68893. doi: 10.1016/j.biopsych.2006.05.024
  13. Степанова Е.В., Кондрашин А.В., Максимова М.С., Турбабина Н.А., Морозова Л.Ф., Морозов Е.Н., Кинкуль-кина М.А., Лазарева А.В., Бражников А.Ю., Сергиев В.П. Латентный хронический токсоплазмоз и шизофрения. Медицинская паразитология 2019; (1): 18-24. doi: 10.33092/0025-8326mp 2019.1.18-24.
  14. Wang T., Wang T., Tang Z.H., Li J.F., Li X.N., Wang X., Zhao Z.J. A potential association between Toxoplasma gondii infection and schizophrenia in mouse models. Exp. Parasitol. 2013; 135(3): 497-502. doi: 10.1016/j.exppara.2013.08.012
  15. Sutterland A.L., Fond G., Kuin A., Koeter M.W.J., Lutter R., van Gool T., Yolken R., Szoke A., Leboyer M., de Haan L. Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr. Scand. 2015; 132(3): 161-79. doi: 10.1111/acps.12423
  16. Jones-Brando L., Torrey E.F., Yolken R. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophrenia Res. 2003; 62(3): 237-44. doi: 10.1016/S0920-9964(02)00357-2
  17. Webster J.P., Lamberton P.H.L., Donnelly C.A., Torrey E.F. Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii’s ability to alter host behaviour. Proceedings of the Royal Society B: Biological Sciences. 2006; 273(1589): 1023-30. doi: 10.1098/rspb.2005.3413
  18. Holub D., Flegr J., Dragomireckâ E., Rodriguez M., Preiss M., Noväk T., Cermhk J., Horâcek J., Kodym P., Libiger J., Höschl C., Motlovâ L.B. Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia. Acta Psychiatrica Scandinavica 2013; 127(3): 227-38. doi: 10.1111/acps.12031
  19. Esshili A., Thabet S., Jemli A., Trifa F., Mechri A., Zaafrane F., Gaha L., Juckel G., Babba H., Jrad B.B. Toxoplasma gondii infection in schizophrenia and associated clinical features. Psychiatry Res. 2016; 245: 327-32. doi: 10.1016/j.psychres.2016.08.056
  20. Wang H.L., Wang G.H., Li Q.Y., Shu C., Jiang M.S., Guo Y. Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive of Toxoplasmaseronegative schizophrenia. Acta Psychiatr. Scand. 2006; 114(1): 40-8. doi: 10.1111/j.1600-0447.2006.00780.x
  21. Fuglewicz A.J., Piotrowski P., Stodolak A. Relationship between toxoplasmosis and schizophrenia: a review. Adv. Clin. Exp. Med. 2017; 26: 1031-6. doi: 10.17219/acem/61435
  22. Stibbs H.H. Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann. Tropical Med. Parasitol. 1985; 79(2): 153-7. doi: 10.1080/00034983.1985.11811902
  23. McConkey G.A., Martin H.L., Bristow G.C., Webster J.P. Toxoplasma gondii infection and behaviour-location, location, location? J. Exp. Biol. 2013; 216(1): 113-9. doi: 10.1242/jeb.074153
  24. Prandovszky E., Gaskell E., Martin H., Dubey J.P., Webster J.P., McConkey G.A. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PloS One 2011; 6(9): e23866. doi: 10.1371/journal.pone.0023866
  25. Skallova A., Kodym P., Frynta D., Flegr J. The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study. Parasitology 2006; 133(5): 525-35. doi: 10.1017/S0031182006000886
  26. Gaskell E.A., Smith J.E., Pinney J.W., Westhead D.R., McConkey G.A. A unique dual activity amino acid hydroxylase in Toxoplasma gondii. PloS One 2009; 4(3): e4801. doi: 10.1371/journal. pone.0004801
  27. Holliman R.E. Toxoplasmosis, behaviour and personality. J. Infect. 1997; 35(2): 105-10. doi: 10.1016/S0163-4453(97)91380-3
  28. Vyas A., Kim S.K., Sapolsky R.M. The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus. Neuroscience 2007; 148(2): 342-8. doi: 10.1016/j.neuroscience.2007.06.021
  29. Berenreiterovâ M., Flegr J., Kubëna A. A., Nëmec P. The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis. PloS One 2011; 6(12) doi: 10.1371/journal.pone.0028925
  30. Hermes G., Ajioka J.M., Kelly K. A., Mui E., Roberts F., Kasza K., Mayr T., Kirisits M.J., Wollmann R., Ferguson D., Roberts C.W., Hwang J.H., Trendler T., Kennan R.P., Suzuki Y., Reardon C., Hickey W.F., Chen L., McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J. Neuroinflammation 2008; 5(1): 48. doi: 10.1186/1742-2094-5-48
  31. Di Cristina M., Marocco D., Galiz, R., Proietti C., Spaccapelo R., Crisanti A. Temporal and spatial distribution of Toxoplasma gondii differentiation into bradyzoites and tissue cyst formation in vivo. Infect. Immun. 2008; 76(8): 3491-501. doi: 10.1128/IAI.00254-08
  32. Guloksuz S., Van Os J. The slow death ofthe concept ofschizophrenia and the painful birth of the psychosis spectrum. Psychol. Med. 2018; 48(2): 229-44. doi: 10.1017/S0033291717001775
  33. Hamdani N., Daban-Huard C., LajnefM., Richard J.R., Delavest M., Godin O., Le Guen E., Vederine F., Lepine J.P., Jamain S., Houenou J., Le Corvoisier P., Aoki M., Moins-Teisserenc H., Charron D., Krishnamoorthy R., Yolken R., Dickerson F., Tamouza R., Leboyer M. Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample. Journal Affective Disorders 2013; 148(2-3): 444-448. doi: 10.1016/j.jad.2012.11.034
  34. Del Grande C., Galli L., Schiavi E., Dell’Osso L., Bruschi F. Is Toxoplasma gondii a trigger of bipolar disorder?. Pathogens. 2017; 6(1): 3. doi: 10.3390/pathogens6010003
  35. Tedla Y., Shibre T., Ali O., Tadele G., Woldeamanuel Y., Asrat D., Aseffa A., Mihret W., Abebe M., Alem A., Medhin G., Habte A. Serum antibodies to Toxoplasma gondii and Herpesvidae family viruses in individuals with schizophrenia and bipolar disorder: a case-control study. Ethiop. Med. J. 2011; 49(3): 211-20.
  36. Miman O., Mutlu E. A., Ozcan O., Atambay M., Karlidag R., Unal S. Is there any role of Toxoplasma gondii in the etiology of obsessive -compulsive disorder? Psychiatry Res. 2010; 177(1-2): 263-5. doi: 10.1016/j.psychres.2009.12.013
  37. Brynska A., Tomaszewicz-Libudzic E., Wolanczyk T. Obsessive-compulsive disorder and acquired toxoplasmosis in two children. Europ. Child. Adolesc. Psychiatry 2001; 10(3): 200-4. doi: 10.1007/s007870170027

补充文件

附件文件
动作
1. JATS XML
下载
##common.cookie##