Clinical case of tick-borne spotted fever rickettsiosis without a rash


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Abstract

Objective. To describe a clinical case of acute rickettsial fever without a rash in a woman from the town of Tekeli, Almaty Region, Republic of Kazakhstan. Materials and methods. The discrepancies in the primary and final diagnoses were analyzed. A retrospective analysis of the clinical manifestations and dynamics of the disease was carried out on the basis of the patient’s medical history. A retrospective serological analysis for immunoglobulins to Rickettsia of the tick-borne spotted fever group was carried out by an enzyme immunoassay. Results. Upon admission, the patient had a fever, intoxication syndrome, hyperemia of the pharynx, hemorrhages of the soft palate, enlarged liver, positive reactions to brucellosis, a history of chronic brucellosis, while no skin rash was observed. The study of serum taken from the patient on day 13 of the disease revealed IgM and IgG against rickettsia of the spotted fever group. Conclusion. There is an urgent need to introduce a comprehensive laboratory and etiological examination of febrile patients for tick-borne rickettsioses in Southern Kazakhstan, including the Almaty Region.

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About the authors

Yulia V. Perfilyeva

Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan

Email: ulya2005@mail.ru
PD, Leading Researcher, Laboratory of Expertise and Diagnosis Almaty, Kazakhstan

Ekaterina O. Ostapchuk

Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan

Email: katyostapchuk@gmail.com
PD, Leading Researcher, Laboratory of Molecular Biology Almaty, Kazakhstan

Dinara A. Naizabayeva

Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan

Email: dino_n7@mail.ru
Junior Researcher, Laboratory of Expertise and Diagnosis Almaty, Kazakhstan

Alena S. Neupokoyeva

Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan

Email: cherusheva_a@mail.ru
Senior Researcher, Laboratory of Expertise and Diagnosis Almaty, Kazakhstan

Nurgeldy A. Turebekov

M. Aikimbayev National Research Center for Especially Dangerous Infections

Email: nirik_1976@mail.ru
PD, Leading Researcher Almaty, Kazakhstan

Lyazzat T. Yeraliyeva

National Research Center of Phthisiopulmonology, Ministry of Healthcare of the Republic of Kazakhstan

Email: l.eralieva@mail.ru
Professor, MD, Deputy Director for Clinical and Scientific Work Almaty, Kazakhstan

Andrey M. Dmitrovsky

Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan; M. Aikimbayev National Research Center for Especially Dangerous Infections

Email: am_dmitr@mail.ru
Professor, MD, Head, Laboratory of Expertise and Diagnosis Almaty, Kazakhstan

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